非酒精性脂肪性肝病患者并发胆固醇性胆结石的发病机制及危险因素

陈永芳; 吴战军

doi:10.3969/j.issn.1001-5256.2013.12.021

非酒精性脂肪性肝病患者并发胆固醇性胆结石的发病机制及危险因素

DOI: 10.3969/j.issn.1001-5256.2013.12.021

1. 济南大学医学与生命科学学院
2. 中国人民解放军第456医院

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2013-04-18
- 出版日期: 2013-12-20

Pathogenesis and risk factors of cholesterol gallstones in patients with non- alcoholic fatty liver disease

Institute of Medicine and Bioscience, University of Ji'nan

摘要

摘要: 流行病学调查表明非酒精性脂肪性肝病(NAFLD)患者胆结石尤其是胆固醇性胆结石患病率较高。NAFLD和胆结石的发生均与肥胖、糖尿病、高脂血症等疾病密切相关,因此NAFLD与胆结石均被认为是代谢综合征的表现。综合国内外多项研究,主要从NAFLD患者并发胆固醇性胆结石的发病机制、危险因素等方面进行探讨,认为其发病可能与胰岛素抵抗、瘦素抵抗、小肠细菌过度生长等因素有关,而年龄、性别、肥胖、血脂紊乱、血糖异常等是其高危因素。了解NAFLD患者并发胆固醇性胆结石的机制及危险因素,对防治NAFLD、胆结石及代谢综合征的发生具有重要意义。
- 脂肪肝 /
- 胆囊结石病 /
- 危险因素
Abstract: Epidemiological investigation suggests that the incidence of gallstones, particularly cholesterol gallstones, is high among patients with non-alcoholic fatty liver disease ( NAFLD) . NAFLD and gallstones are closely related to the diseases such as obesity, diabetes, and hyperlipidemia, so both NAFLD and gallstones are considered the manifestations of metabolic syndrome ( MS) . Many studies both at home and abroad are reviewed to investigate the pathogenesis and risk factors of cholesterol gallstones in patients with NAFLD. It is thought that the pathogenesis may be related to insulin resistance, leptin resistance, small intestinal bacterial overgrowth, etc., and age, sex, obesity, dyslipidemia, and pathoglycemia are risk factors. Understanding the pathogenesis and risk factors of cholesterol gallstones in patients with NAFLD is of great significance for the prevention and treatment of NAFLD, gallstones, and MS.
- fatty liver /
- cholecystolithiasis /
- risk factors

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参考文献(37)

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