乙型肝炎病毒e抗原与免疫耐受
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[]〔1〕MilichDR , JonesJE , HughesJLetal.Isafunctionofthesecretedhepati tisBeantigentoinduceimmunologictoleranceinutero ?[J] ProcNatlAcadSciUSA , 1990 , 86∶6 5 99 []〔2〕MilichDR , JonesJE , McLachlanAetal.Distinctionbetweenimmuno genicityandtolerogenicityamongHBcAgTcelldeterminants :influenceofpeptideMHCinteraction[J] JImmunol, 1989, 14 3∶314 8 []〔3〕MilichDR , JonesJE , HughesJLetal.RoleofTcelltoleranceintheper sistenceofhepatitisBvirusinfection[J] JImmunother, 1993, 14∶2 2 6 []〔4〕ReifenbergK , DeutschleT , WildJetal.ThehepatitisBviruseantigencannotpassthemurineplacentaefficientlyanddoesnotinduceCTLimmunetoleranceinH -2bmiceinutero[J] Virology , 1998, 2 43∶45 []〔5〕MilichDR , McLachlanA , RaneyAKetal.MHC -dependentautoanti bodyinHBeAgtransgenicmiceelicitedwithselfTcellpeptidesandinhibitedwithnonselfpeptides[J] ProcNatlAcadSciUSA , 1991, 88∶4348 []〔6〕MilichDR , PetersonDL , SchodelFetal.Preferentialrecognitionofhep atitisBnucleocapsidantigensbyTh1orTh2cellsinepitopeandmajorhisto compatibilitycomplesdependent[J] JVirol, 1995 , 6 9∶2 776 []〔7〕PaulWEandSederRA .Lymphocyteresponsesandcytokines[J] Cell, 1994, 76∶2 41 []〔8〕MilichDR .InfluenceofT -helpercellsubsetsandcrossregulationinhepatitisBvirusnfection[J] JViralHepat, 1997, 4 (suppl.2 ) 48 []〔9〕MaruyamaT , ThorntonGB , IinoSetal.Useofanti-peptideantibodiesforthedesighofantigen -specificimmunecomplesassays[J] JImmunolMethods, 1992 , 15 5∶6 5 []〔10〕MaruyamaT , MclachlanA , IinoSetal.TheserologyofchronichepatitisBinfectionrevisited[J] JClinInvest, 1993, 91∶2 5 86 []〔11〕JungMC , DiepolderHM , SpenglerVetal.ActivationofaheterogeneoushepatitisBcoreandeantigen -specificCD4+T -cellpopulationduringsero conversiontoanti-HBeandanti -HBsinhepatitisBvirusinfection[J] JVirol, 1995 , 6 9∶335 8 []〔12〕MilichDR , SchodelF , HughesJLetal.thehepatitisBviruscoreandeantigenselicitdifferentThcellsubsets:antigenstructurecanaffectThcellphenotype[J] JVirol, 1997, 71∶2 192 []〔13〕VingerhoetsJ , MichielsenP , VanhamGetal.HBV -specificlymphopro liferativeandcytokineresponsesinpatientswithchronichepatitisB[J] JHepatol, 1998, 2 8∶8
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