乙型肝炎DNA疫苗研究进展
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[]〔1〕DavisHL , MichelML , WhalenRG , etal.DNA -basedimmunizinationinducescontinuoussecretionofhepatitisBsurfaceantigenandhighlevelsofcirculatingantibody〔J〕 HumMolGene, 1993, 2 (11) ∶1847 []〔2〕DavisHL , MccluskieMT , GerinJL , etal.DNAvaccineforhepatitsB :Ev idenceforimmunogenicityinchimpanzeesandcomparsionwithothervaccines〔J〕 ProcNatlAcadSciUSA , 1996 , 93 (14 ) ∶72 13 []〔3〕PrinceAM , WhalenR , BrotmanB , etal.SuccessfulnucleicacidbasedimmunizationofnewbornchimpanzeesagainsthepatitisBvirus〔J〕 Vaccine , 1997, 15 (8) ∶916 []〔4〕GeisslerM , TokushigeK , WandsJ, etal.Cellularandhumoralimmunere sponsetohepatitisBvirusstructuralproteinsinmicefollowingDNA -basedimmunization〔J〕 Gastroenterology , 1997, 112 , 130 7 []〔5〕TriyantniM , JilbertAR , QiaoM , etal.ProtectiveeffeicacyofDNAvac cinesagainstDuckhepatitisBvirusinfection〔J〕 JVirol, 1998, 72 (1) ∶84 []〔6〕borgneSL , MarylineM , GrandRL , etal.Invivoinductionofspecificcyto toxicTlymphocytesinmiceandrhesusmacaquesimmunizedwithDNAvectorencodinganHIVepitopefusedwithhepatitisBsurfaceantigen〔J〕 Virology , 1998, 2 40∶30 4 〔7〕WildJ, GrunerB , MetzgerK , etal.PolyvalentvaccinationagainsthepatitisBsurfaceandcoreantigenusingadicistronicnexpressionplasmid〔J〕 1998, 16 (4 ) ∶35 3 []〔8〕ChowYH , ChiangBL , LeeYL , etal.DevelopmentofTh1andTh2popu lationsandimmuneresponsestohepatitisBvirusDNAvaccinescanbemodu latedbycodeliveryofvariouscytokinegenes〔J〕 JImmunol, 1998, 16 0 (3) ∶132 0 []〔9〕GeisslerM , SchirmbeckR , Reimann , J, etal.CytokinesandepatitisBvirusDNAco-immunizationsenhancecellulurandhumoralimmunerespons estothemiddlebutnottothelargehepatitisBvirussurfaceantigeninmice〔J〕 Hepatology, 1998, 2 8 (1) ∶2 0 2 []〔10〕RobinsonA .DNAbasedvaccines:newpossibilitiesfordiseasepreventionandtreatment〔J〕 CanMedAssocJ, 1995 , 15 2 (10 ) ∶16 2 9 []〔11〕TiollaiosP .DNAimmunizationtohepatitisBsurfaceantigenasanap proachtopreventionandtherapyforhepatitisB〔J〕 JGastroenterolHepatol, 1997, 12 (suppl) ∶S5 3 []〔12〕GramzinskiRA , MillanCL , ObaldiaN , etal.Immuneresponsetohepati tisBDNAvaccineinAotusmonkeys:acomparisonofvaccineformulations , route , andmethodofadministration〔J〕 MolMed , 1998, 4 (2 ) ∶10 9 []〔13〕Danko , P , WolffA .Directgenetransferintomuscle〔J〕 Vaccine , 1994, 12∶14 99 〔14〕TigheH , CoorM , RomanM , etal.Genevaccination :plasmidDNAismorethanjustabluprint〔J〕 ImmunolToday, 1998, 10∶89
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