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乙型肝炎病毒持续感染的可能机制
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[]〔1〕ChisariFVandFerrariC .HepatitisBvirusimmunopathogenesis[J] AnnuRevImmunol, 1995 , 13;2 9 []〔2〕GuidottiLG , RochfordR , ChungJ, etal.Viralclearancewithoutdestruc tionofinfectedcellsduringacuteHBVinfection[J] Science , 1999, 2 84 (5 415 ) ∶82 5 []〔3〕ChisariFV .CytotoxicTcellsandviralhepatitis[J] JClinInvest, 1997, 99∶1742 〔4〕KatoJ, HasegawaK , TorilN , etal.Amolecularanalysisofviralpersis tenceinsurfaceantigen -negativechronichepatitisB[J] Hepatology , 1996 , 2 3∶389 〔5〕LokASF , AkarcaU , GreeneS .MutationsintheprecoreregionofhepatitisBvirusservetoenhancethestabilityofthesecondarystructureofthepregenomeencapsidationsignal[J] ProcNatlAcadSciUSA , 1994, 91;40 77 []〔6〕BertolettiA , CostanzoA , ChisariFV , etal.CytotoxicTlymphocytere sponsetoawild -typehepatitisBvirusepitopeinpatientschronicallyinfect edbyvariantvirusescarryingsubstitutionswithintheepitope[J] JExpMed , 1994, 180∶933 []〔7〕SetteA , AlexanderJ, RuppertJ, etal.antigenanalogs/MHCcomplexesasspecificTcellreceptorantagonists[J] AnnuRevImmunol, 1994, 12 :413 -
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