病毒性肝炎患者血浆部分激素含量与临床的关系

魏倪; 宋军; 汪勤; 杨月华; 苏士香; 侯永生

病毒性肝炎患者血浆部分激素含量与临床的关系

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出版历程
- 出版日期: 2000-04-20

Relationship between levels of partial plasmatic hormones and clinical manifestation in patients with viral hepatitis.

摘要

摘要: 探讨病毒性肝炎VH时机体的神经内分泌变化。以放免法检测 2 97例各型VH及肝硬化（LC）患者血浆血管紧张素Ⅱ （ATⅡ ）、皮质醇（CT）、血栓烷B2 （TXB2 ）、6 -酮 -前列腺素F1α（ 6 -Keto -PGF1α）含量 ,并同步检测肝功能。ATⅡ、CT在急性期均增高。LC组血浆ATⅡ水平呈最高值 ,CT值与对照组无异。TXB2 在重肝组降低。ATⅡ、CT在疾病恢复期下降 ,ATⅡ在加重期增高。ATⅡ、CT、TXB2 与多项肝功相关。VH患者有明显的神经内分泌失调。ATⅡ是与肝病密切相关的激素之一。
- 病毒性肝炎 /
- 血管紧张素Ⅱ /
- 皮质醇 /
- 血栓烷B2 /
- 6-酮-前列腺素F1 α
Abstract: A study on some neuroendocrine changes for viral hepatitis (VH) was undertaken.The serous levels of angiotensn Ⅱ (ATⅡ) , cortisol (CT) , thromboxane B 2 (TXB 2) and 6 ketoperstaglandin F1 α (6 keto PGF1 α) were measured by radioimmunoassay in 297 cases of different types of VH and liver cirrhosis (LC) , in the same time liver functions were detected as well.The levels of both AT Ⅱ and CT obviously elevated in patients in acute period, and AT Ⅱ elevated to the highest level in LC group, while no changes were found for level of CT.The level of TXB 2 obviously decreased in fulminant hepatitis (FH) group.Both levels of AT Ⅱ and CT obviously decreased in restored period but the level of AT Ⅱ elevated in the severe period of disease.A correlation between the several indices of liver functions and AT Ⅱ, CT as well as TXB 2 was found, especially a positive orrelation both the AT Ⅱ and total bilirubin (TBIL) , where as a negative correlation between the AT Ⅱ and albumin (ALB) as well as cholinesterase (CHE) was found.A neuroendocrine imbalance participated in the course of VH.AT Ⅱ is a hormone close correlating clinical manifestation of hepatic diseases.
- Viral hepatitis /
- Angiotensin Ⅱ /
- Cortisol /
- Thromboxane B 2 /
- 6 ketoperstaglandin F1 α

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参考文献(6)

[]〔1〕曾民德 , 萧树东 , 主编 .肝脏与内分泌〔M〕 .第一版 , 北京 :人民卫生出版社 , 1992 , 2 5 .10 5

[]〔2〕MengXJ, WangJL .Arachidonicacidmetabolismingalactosamine/endo toxininducedacuteliverinjuryinrats〔J〕 .JTongjiMedUniv, 1994, 14 (3) ∶16 9.

[]〔3〕SopenaB , Martnez VβzquezC , Fernndez Rodr guezCM , etal.Seruman giotensinconvertingenzymeandC4proteinofcomplementasacombineddiag nosticindexinalcoholicliverdisease〔J〕 .Liver , 1996 , 16 (5 ) ∶30 3 .

[]〔4〕MonteJC , CacariniD , PariseE , etal.Neurohumoralsystemsinpatientswithcirrhosis〔J〕 .RenFail, 1997, 19 (2 ) ∶335 .

[]〔5〕Flisiak R , Prokopowicz D .PlasmaiPGE2andi6 Keto PGF1alphainthecourseoflivercirrhosis〔J〕 .Prostaglandins, 1997, 5 3 (1) ∶11.

[]〔6〕王树人 , 应激〔M〕 .见 :金惠铭 , 主编。病理生理学 , 第四版 , 北京 :人民卫生出版社 , 1997, 10 6 .

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