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Analysis of causes of nonA-E acute hepatitis in sera
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摘要: 探讨血清学非甲 -戊型急性肝炎的病因。采用免疫组织化学和原位杂交技术对 6 5例血清学非甲 -戊型急性肝炎患者的肝组织 ,分别进行乙、庚、丙型肝炎病毒抗原和TT病毒核酸 （TTVDNA）检测。 6 5例肝组织中乙、庚、丙型肝炎病毒抗原及TTVDNA的检出例次分别为 34、32、18和 2 0 ,前两者检出率明显为高 ,差异显著（P <0 0 5 ） ,仍有 10 8%病因不明。在单纯急性乙、庚型肝炎病毒、TT病毒感染及非A -G、TTV感染中 ,部分肝功能组间比较无显著差异 （P >0 0 5 ）。隐匿性的HBV ,庚型肝炎病毒感染是血清学证实为急性非甲 -戊型肝炎的主要病因。部分病例病因分型仍不明确 ,提示有另外的致病因子存在。Abstract: To investigate the etiology of nonA-E acute hepatitis in sera.65 liver tissues of patients with nonA-E acute hepatitis in serum were detected for hepatitis B, C, G, virus antigen and TTV DNA by immunohistochemistry (IHC) or in situ hybridization (ISH) , respectively.Of the 65 liver tissues, hepatitis B、C、G virus antigen and TTV DNA were detected in 34, 18, 32 and 20, respectively.Hepatitis B and G virus antigen were detected signifcantly more than hepatitis C virus antigen or TTV DNA (P<0.01or 0.05) .Difference of partial liver function, among acute simple B, G, TT and nonA-T viral hepatitis serohistologically decided, did not achieve statistical significance (P>0.05) .There were 7 cases (10.8%) with unknown etiology. Silent HBV, and HGV infection were the main cause of non A-E acute hepatitis. The pathogenisis of a proportion of the cases remain unexplained, supporting the hypothesis of the existance of an additional agent.
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Key words:
- nonA-E hepatitis /
- acute hepatitis /
- etiology /
- immunohistochemistry /
- in situ hybridization
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[1]FujiseK , NatioY , SuzukiG , etal DetectionofhepatitisBandGvirusgenomesinserafrom patientswithacutenon A , B , and Chepatitis[J] Hepatology , 1998, 2 8 (4, pt2 ) ∶2 8 [2 ]范金水 , 庄辉 , 朱晓洁 , 等 我国六城市血清学阴性和阳性乙型肝炎临床和流行病学特点的观察比较 [J] 中华预防医学杂志 , 1996 , 30 (增 ) 17 [3]DicksonRC , MelpolderJ SurreptitionshepatitisCvirusinfectiondetectedinthemajorityof patientswithcryptogenicchronichepatitisandnegativeHCVantibodytests[J] JInfectDis, 1997, 76 (1) ∶2 7 -
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