Abstract: To study the treatment effect of α-interferon and xinganbao in chronic hepatitis B.54 cases suffering from chronic hepatitis B were randomly divided into two groups.There were 24 cases in treatment group (man 18 cases, woman 6 cases, average age 37.7 year) , and 30 cases in control group (man 22 cases, woman 8 cases, average age 35.6 year) .The cases in the treatment group were given small dosage of α-2b interferon (100MU, im, qd) and xinganbao (6 capsules, po, tid) .The control was treated with Huachansu (4ml im, gd) for 3 months.The entire course was 3 months.The liver function and HBV-M before and after the treatment were detected result In the treatment, the negative transfer rate in anti-HBcIgM, HBeAg, and Pre-S 2 were 50%, 72.2%and60%, respectively.In the control, they were 60%, 60%, and47.8%, respectively.And only the negative transfer rate of HBeAg is high significantly (P<0.05) .Conclusion The negative transfer rate of HBeAg in the treatment was higher them it in the control.It supports Ha zhong-ying S report in which the negative transfer rate of HBeAg with large dosage α-interferon was 65.9%and zhang xiao-rong S report in which its rate was 66.6%.