缺陷型Ⅱ型TGF-β受体治疗肝纤维化的研究进展

邵宝妹

缺陷型Ⅱ型TGF-β受体治疗肝纤维化的研究进展

邵宝妹

华西医科大学免疫教研室!四川成都610041

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中图分类号: R575.2
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出版历程
- 出版日期: 2001-03-20

Shao BaoMei

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参考文献(10)

[1]陈乃玲 , 贾克明 , 肝纤维化发生机制的研究进展 [J]。中华内科杂志 , 1999, 38 (2 ) ∶139.

[][2 ]GeorgeJ , RoulotD , KotelianskyVE , etal.InvivoinhibitionofratstellatecellactivationbysolubletransforminggrowthfactorβtypeⅡreceptor :Apotentialnewtherapyforhepaticfibrosis[J] .ProcA cadSciUSA , 1999, 96 (2 2 ) ∶12 719.

[3]TaniguchiA , MatsuzakiK , NakanoK , etal.Ligand dependentandindependentinteractionswiththetransforminggrowthfactorβtypeⅡandⅠreceptorsubunitsresideintheaminoterminalportionoftheectodomainofthetypesubunitⅢ [J] .InvitroCellDev.Biol., 1998, 34 (3) ∶2 32 .

[4]LinHY , MoustakasA , KnausP , etal.Thesolubleexoplasmicdo mainofthetypeⅡtransforminggrowthfactor (TGF) βreceptor[J] .J.Bio .Chem , 1995 , 2 70 (6 ) ∶2 747.

[][5 ]WieserR , AttisanoL , WranaJL , etal.Signalingactivityoftrans forminggrowthfactorβtypeⅡreceptorslackingspecificdomaininthecytoplasmicregion[J] .MolecularandcellularBiology , 1993 , 13 (12 ) ∶72 39.

[][6 ]IsakaY , AkagiY , AndoY , etal.Genetherapybytransforminggrowthfactorβreceptor IgGFcchimerasuppressedextracellularmatrixaccumulationinexperimentalglomerulonephritis[J] .KidneyEnter, 1999, 5 5 (2 ) ∶46 5 .

[7]SmithJD , BryantSR , CouperLL , etal.SolubletransforminggrowthfactorβtypeⅡreceptorinhibitsnegativeremodeling , fibroblasttransdifferentiationandintimallesionformationbutnotendothelialgrowth[J] .CircRes, 1999, 84 (10 ) ∶12 12 .

[8]UenoH , SakamotoT , NakamuraT , etal.Asolubletransforinggrowthfactorβreceptorexpressedinmusclepreventsliverfibrogen esisanddysfunctioninrats.HumGeneTher, 2 0 0 0 , 11 (1) ∶33.

[9]YamamotoH , UenoH , OoshimaA , etal.Adenovirus mediatedtran ferofatruncatedtransforminggrowthfactor β (TGFβ) typeIrecep torcompletelyandspecificallyabolishesdiversesignalingbyTGF -βinvascularwallcellsinprimaryculture[J] .J.Bio .Chem , 1996 , 2 71 (2 7) ∶16 2 5 3.

[][10 ]QiZ , AtsuchiN , OoshimaA , etal.Blockadeoftypeβtransforminggrowthfactorsignalingpreventsliverfibrosisanddysfunctionintherat[J] .Proc.Natl.Acad .Sci.USA , 1999, 96 (5 ) ∶2 345 .

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