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Study on Octreotide Induce apoptosis of Human Hepatocelluler Carcinoma Cells
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摘要: 应用光镜、电镜及Westernblot法系统地观察了 1μg/ml奥曲肽对人肝癌细胞株SMMC - 772 1的形态及其内Caspase - 3的表达的影响。结果发现奥曲肽能引起SMMC - 772 1细胞形态改变 ,出现核浓缩、线粒体空泡化、微绒毛减少等变化 ,而且能促进Caspase - 3的表达并使其激活 ,从而诱导肝癌细胞凋亡Abstract: To study Octreotide inducing apoptosis of hepatocellular carcinoma (HCC) cells, the morphologic changes and the expression of Caspase 3 were observed with light, electron microscope and Western blot assay.It showed that Octreotide could induce condensation of nuclear, vacuolar degeneration of mitochondria, reduction of microvillus, and so on.We can also conclude that Octreotide can strengthen the expression of Caspase 3 and activiate it so that inducing apoptosis of HCC cells.
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Key words:
- Octreotide /
- Hepatocellular carcinoma cells /
- Caspase 3 /
- Apoptosis
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