中国乙型肝炎病毒B基因型、C基因型与干扰素疗效的关系

李庭明; 朱幼芙; 何海棠; 毛乾国; 吴爱华; 梁蔚芳; 骆抗先

中国乙型肝炎病毒B基因型、C基因型与干扰素疗效的关系

基金项目:

军队九五研究基金 (NO.0 1Z0 4 6)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2005-01-20

The relation between chinese hepatitis B virus genotype B C and efficacy of interferon-α.

Research funding:

摘要

摘要: 探讨中国乙型肝炎病毒基因型与干扰素α疗效的关系。用PCR -限制性酶切片段长度多态性方法分析乙型肝炎病毒基因型 ,并研究 1998 1～ 2 0 0 2 4南方医院门诊和住院慢性乙型肝炎患者的一般人口学、ALT、HBVDNA、肝脏活检组织病理以及干扰素治疗效果。B基因型 70例 ,C基因型 6 0例 ,两基因型间一般人口学、ALT、HBVDNA、肝脏活检组织病理无统计学差异 ,干扰素治疗效果同样没有显著性差异。HBVB、C基因型感染的慢性乙型肝炎患者临床无统计学差异 ,可能与两组患者有着相似的免疫背景有关
- HBV /
- 基因型 /
- 干扰素-α /
- 慢性乙型肝炎
Abstract: To investigate the relation between chinese hpatitis B virus (HBV) genotype and efficacy of interferon-α.HBV genetype was testified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) .Common demography, Alanine aminotransferase (ALT) , HBVDNA, liver biopsy, and efficacy of interferon-α of chronic hepatitis B (CHB) patients of Nanfang Hospital during 1998.1-2002.4 were surveyed.Patients with CHB caused by HBV B or C genotype have not any significante difference neither in common demography, ALT, HBV DNA, liver biopsy, nor in efficacy of interferon-α Patients infected with HBV B or C genotype have no significante difference in clinic, probably correlated to the similar immune background of two groups.
- HBV /
- genotype /
- interferon-α /
- chronic hepatitis B

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参考文献(24)

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