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摘要: 分析IL-18、IL-4、IFNγ在慢性乙型重型肝炎中的作用。采用固相夹心法酶联免疫吸附试验检测25例正常人,35例慢性乙型肝炎,45例慢性乙型重型肝炎患者血清IL-18、IL-4、IFNγ的水平。结果发现1.IL-18、IL-4三组间均有显著性差异,IFNγ慢性肝炎与慢重肝无显著性差异,但均显著高于正常对照组;2.IL-18、IL-4生存组显著低于死亡组(P<0.05),IFNγ两组间无显著性差异;3.重型肝炎重症期与康复期比较,IL-18、IFNγ康复后均显著性下降(P<0.05);4.慢重肝组IL-4与IL-18呈正相关(r=0.6,P<0.01);IL-4与IFNγ呈正相关(r=0.54,P<0.01)。IL-18、IL-4、IFNγ参与了重型肝炎的发病及转归过程,在慢性重型肝炎的免疫病理中有重要作用。
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[1]覃小敏, 宁琴.重型肝炎发病的分子机制研究进展[J].国外医学.流行病学传染病学分册, 2004, 31∶150-152. [1]覃小敏, 宁琴.重型肝炎发病的分子机制研究进展[J].国外医学.流行病学传染病学分册, 2004, 31∶150-152. [2]杜维波.白细胞介素18与炎症性肝病[J].临床肝胆病杂志, 2002, 18 (3) ∶151-153. [2]杜维波.白细胞介素18与炎症性肝病[J].临床肝胆病杂志, 2002, 18 (3) ∶151-153. [3]Nakanishi K.Regulation of Th1 and Th2 immune responses by IL-18[J].Kekkaku, 2002, 77∶87-93. [3]Nakanishi K.Regulation of Th1 and Th2 immune responses by IL-18[J].Kekkaku, 2002, 77∶87-93. [4]Nakanishi K, Yoshimoto T, Tsutsui H, et al.interleukin-18 is a u-nique cytokine that stimulates both Th1 and Th2 responses depending onits cytokine milieu[J].Cytokine Growth Factor Rev, 2001, 12∶53-72. [4]Nakanishi K, Yoshimoto T, Tsutsui H, et al.interleukin-18 is a u-nique cytokine that stimulates both Th1 and Th2 responses depending onits cytokine milieu[J].Cytokine Growth Factor Rev, 2001, 12∶53-72. [5]Shi Z, Wakil AE, Rocket DC.Strainspecific differentces in mouse hepat-ic wound healing are mediated by divergent T helper cytokine responses[J].Proc Nat1 Acad Sci USA, 1997, 94∶100663. [5]Shi Z, Wakil AE, Rocket DC.Strainspecific differentces in mouse hepat-ic wound healing are mediated by divergent T helper cytokine responses[J].Proc Nat1 Acad Sci USA, 1997, 94∶100663. [6]Tankijvanich P, Vimolket T, Theamboonlers A, et al.Serum interleukin-6 and interferon-gamma levels in patients with hepatitis B-associatedchronic liver disease[J].Asian Pac J Allergy Immunolm, 2000, 18∶109-114. [6]Tankijvanich P, Vimolket T, Theamboonlers A, et al.Serum interleukin-6 and interferon-gamma levels in patients with hepatitis B-associatedchronic liver disease[J].Asian Pac J Allergy Immunolm, 2000, 18∶109-114. [7]Chisari FV.Hepatitis B virus transgenic mice∶insights into the virus andthe disease[J].Hepatology, 1995, 22∶1316-1325. [7]Chisari FV.Hepatitis B virus transgenic mice∶insights into the virus andthe disease[J].Hepatology, 1995, 22∶1316-1325.
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