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肝纤维化中TGF-β/Smad信号通路

徐丽红 郑勇

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肝纤维化中TGF-β/Smad信号通路

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  • 中图分类号: R575.2

  • [1]Wataru Wada, Hiroyuki Kuwano, Yoshihisa Hasegawa et al.The depen-dence of transforming growth factor-β-Induced collagen production onautocrine factor activin a in hepatic stellate cells[J].Endocrinology, 2004, 145∶2753-59.
    [2] Rong Shao, Zengdun Shi, Philip J.Gotwals, et al.Cell and molecularregulation of Endothelin-1 production during hepatic wound healing[M].Cell Biol, 2003, 14∶2327-41.
    [3]Elisadetta del Re, Jodie L.Babitt, Alnoor Pirani, et al.In the Absenceof TypeⅢReceptor, the transforming growth factor (TGF) -βtypeⅡ-βReceptor requires the typeⅠReceptor to bind TGF-β2[J].BiolChem, 2004, 279∶22765-772.
    [4] K.L.Stenvers, M.L.Tursky, K.W.Harder, et al.Heart and liverdefects and reduced transforming growth factorβ2 sensitivity in transform-ing growth factorβTypeⅢreceptor-deficient embryos[M].Cell Biol, 2003, 23∶4371-85.
    [5] Justin P.Annes, John S.Munger, Daniel B Rifkin.Making sense of la-tent TGFβactivation[J].Cell Sci, 2003, 116∶217-224.
    [6] L.Attisano.JL.Wrana.Signal transduction by the TGF-βsuperfamily[M].Science, 2002, 296∶1646-1647.
    [7]Steffen K.Meurer, Lidia Tihaa, Birgit Lahme, et al.Identification ofendoglin in rat hepatic stellate cells∶new insights into TGF-βreceptorsignaling[J].J Biol Chem, 2005, 280∶3078-3087.
    [8]D.Roulot, AM.Sevcsik, T Coste.Role of transforming growth factorbeta typeⅡreceptor in hepatic fibrosis∶studies of human chronic hepati-tisc and experimental fibrosis in rats[J].Hepatology, 1999, 29∶1730-1738.
    [9] G.J.Inman, F.J.Nicola s, C.S.Hill.Nucleocytoplasmic shuttlingof Smads 2, 3, and 4 permits sensing of TGF-βreceptor activity themolecular mechanisms that control Smad subcellular[M].Cell, 2002, 10∶283-294.
    [10]Daisuke Goto, Hiroshi Nakajima, Yumiko Mori, et al.Interaction be-tween Smad Anchor for Receptor Activation and Smad3 Is Not Essentialfor TGF-β/Smad3-Mediated Signaling[J].Biochemical and Biophysi-cal Research Communication, 2001, 281∶1100-1105.
    [11] Chenghai Liu, D.A.Marianna, et al.Smads 2 and 3 are differentiallyactivated by transforming growth factor-β (TGF-β) in quiescent andactivated hepatic stellate cells[J].J Biol Chem, 2003, 278∶11721-11728.
    [12]E.Piek, W.Ju, J.Heyer, et al.Functional characterization of trans-forming growth factor b Signaling in Smad2-and Smad3-deficient fi-broblasts[J].Biol Chem, 2001, 276∶19945-19953.
    [13]Aki Hanyu, Yasuhiro Ishidou, Takanori Ebisawa.The N domain ofSmad7 is essential for specific inhibition of transforming growth factor-βsignaling[J].J Cell Bio, 2001, 155∶1017-1027.
    [14]Inagaki Y, Mamura M, Kanamaru Y et al.Constitutive phosphorylationand nuclear localization of Smad3 are correlated with increased collagengene transcription in activated hepatic stellate cells[J].J Cell Physiol, 2001, 87∶117-123.
    [15]Shigeki Tsukada, John K.Westwick, Kenichi Ikejima, et al.SMADand p38 MAPK signaling pathways independently regulateα1 collagengene expressing in unstimulate and TGF-βstimulated hepatic stellatecells[J].J Biol Chem, 2005, 280∶10055-10064.
    [16] Qi Cao, Ki M.Mak, Charles S.Lieber.DLPC decreases TGF-β1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells[J].Am J Physiol Gastrointest Liver Physiol, 2002, 283∶1051-1061.
    [17] Carmen G.Lechuga, Zamira H.Hernández-Nazara, José-AlfredoDomínguez Rosales, et al.TGF-β1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involvingp38MAPK, PI3-kinase, AKT, and p70S6K[J].Am J Physiol GastrointestLiver Physiol, 2004, 287∶974.
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  • 出版日期:  2006-01-20
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