[1]Radziw ill G, TuckerW, SchallerH.Mutational analysis of the bepa-titis B virus P gene product:domain structure and Rnase H activity[J].J V irol, 1990, 64∶613-20.
|
[2]Poch O, Sauvaget I, D elarue M, et al.Identification of four con-served motifs among the RNA-dependent polym erase encod ing ele-m ents[J].EMBO J, 1989, 18∶3867-74.
|
[3]Seeger C, Manson W S.Hepatitis B virus b iology[J].M icrob iolMolB iol Rev, 2000, 64∶51-68.
|
[4]X iong X, Yang H, Christopher E, et al.In vitro evaluation of hepa-titis B virus polym erase mutations associated w ith fam ciclovir resist-ance[J].Hepatology, 2000, 31∶219-24.
|
[5]M cGarveyM J, Gold in RD, Karayiann is P, et al.The expression ofhepatitis B virus polym erase in hepatocytes during chron ic HBV in-fection[J].J V iralHepat, 1996, 3∶6773.
|
[6]Foster GR, Golden RD, Hay A, et al.Expression of the term inalprotein of hepatitis B virus is associated w ith failure to respond to in-terferon therapy[J].Hepatology, 1993, 17∶75762.
|
[7]Tavis JE, Massey B, Gong Y.The duck hepatitis B virus polym eraseis activated by its RNA packaging signal, epsilon[J].J V irol, 1998, 72∶5789-96.
|
[8]Hussain M, Lok AS.Mutations in the hepatitis B virus polym erasegene associated w ith antiviral treatm ent for hepatitis B[J].J V iralHepat, 1999, 6∶183-94.
|
[9]ChenWN, Oon CJ.Human hepatitis B virusmutants:sign ificance ofmolecu lar changes[J].FEBS, 1999, 453∶237-242.
|
[10]M elegariM, Scaglion i PP, W ands JR.Hepatitis B virusmutants as-sociated w ith 3TC and fam ciclovir adm in istration are replication de-fective[J].Hepatology, 1998, 27∶628-33.
|
[11]B lum HE, Galun E, L iang TJ, et al.Naturally occurring masseusemutation in the polym erase gene term inating hepatitis B virus replica-tion[J].J V irol, 1991, 65∶1836-42.
|
[12]季伟.嗜肝DNA病毒聚合酶的研究进展[J].国外医学.流行病学传染病学分册, 2002, 39∶155-157.
|
[13]Feitelson MA, m illman I, Duncan GD, et al.Presence of antibod-ies to the polym erase gene product (s) of hepatitis B and woodchuckhepatitis virus in natural and experim ental infections[J].JM ed V ir-ol, 1988, 24 (2) ∶121-136.
|
[14]Lega L, RestiM, RossiME, et al.Hepatitis B virus:New markersand their immunology[J].Ped iatrM ed Ch ir, 1993, 15 (1) ∶5-10.
|
[15]M cC lary H, Koch R, Ch isari FV, et al.Relative sensitivity of hep-atitis B virus and other hepatotrop ic viruses to the antiviral effects ofcytok ines[J].J V irol, 2000, 74∶2255-64.
|
[16]W ieland SF, Gu idotti LG, Ch isari FV.Intrahepatic induction of al-pha/beta interferon elim inates viralRNA-contain ing capsids in hep-atitis B virus transgen ic m ice[J].J V irol, 2000, 74∶4165-73.
|
[17]M ichalak TI, Hodgson PD, Church ill ND.Posttranscriptional inh i-b ition of class Imajor h istocompatib ility complex presentation on hep-atocytes and lymphoid cells in chron ic woodchuck hepatitis virus in-fection[J].J V irol, 2000, 74∶4483-94.
|
[18]骆抗先.乙型肝炎基础和临床[M].第2版.北京:人民卫生出版社, 2001∶21-24.
|
[19]D e C lercq E.Perspectives for the treatm ent of hepatitis B virus in-fections[J].Int J Antim icrob Agents, 1999, 12∶81-95.
|
[20]Shae T, Locarn in i SA.Hepatic purine and pyrim id ine m etabolism:implications for antiviral chemotherapy of viral hepatitis[J].L iver, 1995, 15∶169-84.
|
[21]Santanton io T, mazzolaM, Iacovazzi T, et al.Long-term follow-up of patients w ith anti-HBe/HBV DNA-positive chron ic hepatitisB treated for 12 months w ith lam ivud ine[J].J Hepatol, 2000, 32∶300-6.
|