细胞因子与乙肝肝硬化骨质疏松的关系

王义国; 刘倩; 王文奇; 陈自平; 闫明先

细胞因子与乙肝肝硬化骨质疏松的关系

基金项目:

山东省自然科学基金资助(981154505)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2006-03-20

Relationship of cytokines and osteoporosis in patients with hepatitis B cirrhosis

Research funding:

摘要

摘要: 探讨细胞因子在乙肝肝硬化骨质疏松（OP）发病机制中的作用。检测61例乙肝肝硬化患者的骨密度、血清骨钙素（BGP）,白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、尿骨胶原交联（Crosslaps）,并与30例健康者对照。肝硬化组尺桡骨密度较对照组明显降低。肝硬化组血清BGP水平较对照组明显降低,其中OP组较NOP降低更明显,尿Crosslaps水平肝硬化组较对照组明显升高,其中OP组较NOP升高更明显,血清BGP水平与尺桡骨密度呈正相关。OP组尿Crosslaps水平与尺桡骨密度呈负相关,而NOP无相关。肝硬化组血清IL-1β、IL-6、TNF-α水平较对照组明显升高,且OP组较NOP组显著升高;肝硬化组IL-1β、IL-6、TNF-α水平与尺桡骨密度呈负相关;其中OP组较NOP组相关性更明显。乙肝肝硬化患者存在着不同程度的骨质疏松,L-1β、IL-6、TNF-α在其过程中起到了重要的作用,适当降低体内IL-1β、IL-6、TNF-α水平,对乙肝肝硬化骨质疏松的防治可能具有重要意义。
- 乙肝肝硬化 /
- 骨钙素 /
- 细胞因子 /
- 尿骨胶原交联 /
- 骨质疏松
Abstract: To study the relationship between cytokines and osteoporosis in patients with hepatitis B cirrhosis.Bone mineral desity (BMD) and serum levels of BGP、IL-1β、IL-6、TNF-α、urine crosslaps were detected in 61 cirrhosis patients and 30 agematched healthy controls.BMD and the serum levels of BGP in patients with hepatitis B cirrhosis were lower than those in control group.And the serum levels of BGP were much lower in OP group than those in NOP group.The leels of serum BGP had positive relation with the changes of BMD.A significant negative relation was found between urine crosslaps and BMD in OP group but there were no significant relation between them in NOP group.The serum levels of IL-1β、IL-6、TNF-α and urine crosslaps were higher in cirrhosis group than those in the controls, and were much higher in OP group than in NOP group.BMD had negative relations with serum levels of cytokines and urine crosslaps.Osteoporosis exists in cirrhosis patients.Elevation of serum IL-1β、IL-6、TNF-α can accelerate bone resorption and cause osteoporosis.Decrease of IL-1β、IL-6、TNF-α may be very important for prevention and treatment of osteoporosis.
- hepatitis B cirrhosis /
- serum cytokine /
- urine crosslaps /
- osteoporosis /

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参考文献(8)

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