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Analysis of liver histopathology in asymptomatic chronic HBV carriers
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摘要: 了解ALT正常的HBV慢性携带者(ASC)的肝组织病理改变状况,探讨其临床意义及其与HBVDNA、HBeAg的关系。对32例ALT正常的HBV慢性携带者行快速经皮肝穿刺术取肝组织,研究肝组织炎症活动度及纤维化程度分级分期;ELISA法检测血清HBVM,PCR法检测血清HBVDNA。结果没有真正的健康ASC(病理状态为G0S0),32例ASC中,G1S0有15例,G1S1有13例,G2S1有4例;肝组织学的炎症活动及纤维化改变程度HBVDNA阳性组明显重于HBVDNA阴性组,男、女之间、HBeAg定性检测及HBVDNA水平的比较,无明显差异。
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关键词:
- 慢性HBV携带者(ASC) /
- HBVDNA /
- 肝组织病理学 /
- 纤维化 /
- 炎症活动度
Abstract: To investigate the influences of serum HBVDNA and HBeAg levels on the changes and clinic values of liver histopathology in asymptomatic chronic hepatitis B virus carriers (ASC) .The changes of liver were evaluated histopathologically in 32 ASC by transepidermal liver biopsy method.The liver tissue was dyed with haematoxylin-eosin (HE) staining for study of pathologic grading and staging of hepatic liver inflammation and fibrosis.HBV-markers were detected by enzymelinked immunosorbent assay (ELISA) method.Serum HBVDNA levels were measured by polymerase chain reaction (PCR) method.It can be concluded that ASC are not absolute equal to health carriers.Of 32 carriers, there are 15 persons with G1S0, 13 persons with G1S1, 4 persons with G2S1.The rate of pathologic grading and staging of hepatic liver inflammation and fibrosis was not significantly changes in 20 male carriers compared with 12 female carriers (P>0.05) .The rate of those in HBVDNA (+) carriers showed significant different from those of HBVDNA (-) carriers (P<0.05) .The rate of those in HBeAg (+) and high copy groups (HBVDNA>1.0×107cp/ml) carriers showed no significant difference from those of HBeAg (-) and low copy groups (HBVDNA<1.0×107cp/ml) respectively (P>0.05) .-
Key words:
- asymptomatic chronic hepatitis B virus carrier /
- HBVDNA /
- HBeAg /
- liver histopathology /
- inflammation
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