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The diagnosis value of hyaluronic acid, typeⅢprocollagen, type collagen and proline dipeptidase in liver fibrosis
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摘要: 探讨肝病患者血清透明质酸(HA),Ⅲ型前胶原(PCⅢ),Ⅳ型胶原(CⅣ)及脯氨酸肽酶(PLD)水平与肝纤维化程度的关系。用酶联免疫(ELISA)法及生化比色法检测225例各种肝病患者血清中HA、PCⅢ、CⅣ及PLD水平,并与肝活检病理炎症分级和纤维化分期相比较。四项指标与肝组织炎症坏死及纤维化程度均呈显著相关(P<0.05)。HA、PCⅢ及CⅣ与肝纤维化相关性高于炎症,PLD与炎症的相关性高于纤维化。血清学指标与肝组织病理病变程度一致,联合检测肝病患者血清HA、PCⅢ、CⅣ及PLD水平,既可反映肝纤维化严重程度,又能了解肝坏死情况,为临床诊断治疗提供参考。Abstract: To determine the relationship between hyaluronic acid (HA) , typeⅢ procollagen (PCⅢ) , type-Ⅳ collagen (CⅣ) or proline dipeptidase (PLD) and degree of liver fibrosis.HA, PCⅢ, CⅣ and PLD in the serum from 225 pa-tients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationshipwith the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation (P<0.05) between the four indexes and the degree of inflammation, necrosis and fibrosis.The serological indexes are in ac-cordance with the pathological degree of live tissues.It could reflect both the severe degree of hepatofibrosis and the statusof hepatocellular necrosis by co-measuring HA、PCⅢ or CⅣ and PLD in the serum, that provides reference for clinicaldiagnosis and treatment.
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Key words:
- hyaluronic acid /
- typeⅢ procollagen /
- type-Ⅳ collagen /
- proline dipeptidase /
- hepatofibrosis /
- diagnosis
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