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The protective effect of rhKD/APP on liver injured by D-galactosamine in rats
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摘要: 用D-氨基半乳糖致大鼠肝损伤,以研究rhKD/APP对大鼠肝损伤的保护作用。建立D-氨基半乳糖大鼠肝损伤模型,设空白对照组、模型组、rhKD/APP小剂量组、中剂量组、大剂量组、对照药物抑肽酶组。观察大鼠血清丙氨酸转氨酶（ALT）、天门冬氨酸转氨酶（AST）、总蛋白（TP）、碱性磷酸酶（ALP）、白蛋白（ALB）及肝组织丙二醛（MDA）的含量变化。rhKD/APP可显著降低大鼠血清ALT、AST、ALP的活性及肝组织MDA含量,抑制ALB、TP的降低。rhKD/APP对D-氨基半乳糖所致大鼠肝损伤具有保护作用。Abstract: To investigate the protective effect of rhKD/APP on liver injured by D-galactosamine in rats.The rat liver injury model was induced by D-galactosamine.rhKD/APP was given by different dose, compared with controls and aprotinin.The levels of ALT, AST, TP, ALB, ALP in serum and MDA in hepatic tissue were mesured.rhKD/APP can significantly decresease the activities of ALT, AST, ALP, and the content of MDA, and inhibit the decrease of ALB and TP.rhKD/APP has a protective effect on liver injured by D-galactosamine in rats.
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Key words:
- rhKD/APP /
- D-galactosamine /
- liver injury
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