中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

IL-18在病毒性肝炎发病机制中的作用研究进展

刘兰 唐先梅 刘佩芝

引用本文:
Citation:

IL-18在病毒性肝炎发病机制中的作用研究进展

详细信息
  • 中图分类号: R512.6

  • [1]Okamura H, Tsutsui H, Komatsu T, et al.Cloning of a newcytokinethat induces IFN-γproduction by T cells[J].Nature, 1995, 378 (1) ∶88-91.
    [2]Olee T, Hashimoto S, Quach J, et al.IL-18 is produced by articu-lar chondrocytes and induces proinflammatory and catabolic responces[J].Immunol, 1999, 162∶1096-1100.
    [3]Fantuzzi G, Dinarello CA.Interleukin-18 and Interleukin-1β:two cytokine substrates for ICE (caspase-1) [J].Clin Immunol, 1999, 19∶1-11.
    [4]Dinarello CA.Interleukin-18[J].Methods, 1999, 19 (1) ∶121-132.
    [5]Nowak M, Gaines GC, Rosenberg J, et al.LPS-induced liver inju-ry in D-galactosamine-sensitized mice requires secreted TNF-αand the TNF-p55 receptor[J].Am J Phsiol Regul Integr CompPhysiol, 2000, 278 (5) ∶1202-1209.
    [6]Josephs MD, Bahjat FR, Fukuzukak, et al.Lipopolysaccharideanand D-galactosamine induced hepatic in jury is mediated by TNF-αand not by Fas ligand[J].AmJ Physiol Regul Inter Comp Physiol, 2000, 278 (9) ∶1196-1201.
    [7]Tominaga K, Yoshimoto T, Torigoe K, et al.IL-12 synergizes withIL-18 or IL-1βfor IFN-γproduction from human T cells[J].Int Immunol, 2002, 12∶151-160.
    [8]Tsutsui H, Matsui K, Okamura H, et al.Pathophysiological roles ofinterleukin-18 in inflammatory liver diseases[J].Immunol Rev, 2000, 174∶192-209.
    [9]Nakaniski K, Yoshimoto T, Tsutsui H, et al.Interleukin-18 regu-lates both Th1 and Th2 responses[J].Annu Rev Immunol, 2001, 19 (2) ∶423-474.
    [10]Aller MA, Arias J L, Nava MP, et al.Posttraumatic InflammationIs a Complex Response Based on the Pathological Expression of theNervous, Immune, and Endocrine Functional Systems[J].Experi-mental Biology Medicine, 2004, 229 (1) ∶170-181.
    [11]Saeed A, Jortani, Sumanth D, et al.Strategies for Developing Bio-markers of Heart Failure[J].Clinical Chemistry, 2004, 50 (2) ∶265-278.
    [12]Milich DR.Influence of T-helper cell subsets and crossregulationin hepatitis B virus infection[J].Viral Hepat, 1997, 4∶48-59.
    [13]Maruyama T, Schodel F, Iino S, et al.Distinguishing between a-cute and symptomatic chronic hepatitis B virus infection[J].Gastro-enterology, 1994, 106 (4) ∶1006-1015.
    [14]文维群, 章廉, 肖红, 等.乙型肝炎病毒感染者IL-18基因的转录及表达[J].中华医学杂志, 2001, 81 (11) ∶655-658.
    [15]韩显林, 王文冰.HBV感染者PBMC培养上清液IL-18水平的监测及意义[J].辽宁医学杂志, 2005, 19 (3) ∶147-148.
    [16]杜维波, 许洁, 甘建和, 等.病毒性肝炎患者血清IL-12及IL-18水平变化的研究[J].临床肝胆病杂志, 2002, 18 (4) ∶215-216.
    [17]孔武明, 王湖荣, 任喜民, 等.白细胞介素-18在慢性乙型肝炎发病机理中作用探讨[J].陕西医学杂志, 2001, 30 (6) ∶323-325.
    [18]刘家秀, 史亚明, 黄加忠, 等.慢性乙肝患者血清SICAM-1与IL-18的变化及相关性研究[J].Chin J Clini Hepatol, 2003, 19 (4) ∶224-225.
    [19]姜荣龙, 卢桥生, 郭亚兵, 等.Th1/Th2细胞在慢性乙型肝炎病毒感染中的作用[J].第一军医大学学报, 2000, 20 (2) ∶103-105.
    [20]黄利华, 蒋跃明, 谢志萍, 等.慢性乙型重型肝炎患者外周血白细胞介素18、血白细胞介素4、γ干扰素的变化[J].临床荟萃, 2005, 20 (8) ∶436-437.
    [21]唐宝璋, 陈阜, 陈红英, 等.重型肝炎患者血清内毒素、白细胞介素 (IL) -4、IL-18水平的研究[J].中华内科杂志, 2004, 43 (2) ∶137-138.
    [22]Yumoto E, Higashi T, Nouso K, et al.Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in pateints with acutehepatitis and fulminant hepatic failure[J].Gastroenterol Hepatol, 2002, 17 (3) ∶285-294.
    [23]Finotto S, Siebler J, Hausding M, et al.Severe hepatic injury ininterleukin 18 (IL-18) transgenic mice:a key role for IL-18 inregulating hepatocyte apoptosis in vivo[J].Gut, 2004, 53 (3) ∶392-400.
    [24]田小平, 朱崇尧, 何浩明, 等.慢性乙型肝炎患者血清IL-6、IL-10、IL-18水平与HA、PCⅢ浓度相关性研究[J].淮海医药, 2004, 22 (2) ∶87-89.
    [25]杨小云, 观晓辉, 曾宏, 等.乙型肝炎肝硬化患者血清IL-18、IFN-γ水平变化的研究[J].现代中西医结合杂志, 2005, 14 (4) ∶1815-1816.
    [26]曾宏.乙型肝炎失代偿期肝硬化患者血清内毒素、IL-12、IL-18水平的检测及意义[J].广东医学院学报, 2005, 23 (3) ∶264-265.
    [27]张玲英, 杜琼, 洪华, 等.白细胞介素-18与病毒载量在慢性乙型肝炎中的对比研究[J].江西医学检验, 2004, 22 (3) ∶213-214.
    [28]龚作炯, 吴亚斌, 杨丽华.慢性乙型肝炎患者血清白细胞介素10、12、18、干扰素-γ和前C/C区变异的关系[J].武汉大学学报 (医学版) , 2005, 26 (1) ∶121-123.
    [29]王琳, 陆荫英, 成军, 等.白细胞介素-18逆转录病毒载体的构建及抗乙型肝炎病毒的研究[J].解放军医学杂志, 2002, 27 (8) ∶699-701.
    [30]Kiminori K, Kazuhiro K.Interleukin-18 Inhibit Hepatitis B VirusReplication in the Liver of Transgenic Mice[J].J Virol, 2002, 76 (21) ∶10702-10707.
    [31]Sakao Y, Takeda K, Tsutsui H, et al.IL-18-deficient mice areresistant to endotoxin-induced liver injury but highly susceptible toendotoxin shock[J].Int Immunol, 1999, 11 (3) ∶471-480.
    [32]孙颖, 陈焕永, 王菲, 等.白细胞介素-18对慢性乙型肝炎患者外周血单个核细胞的作用及意义[J].中华肝脏病杂志, 2003, 11 (8) ∶470-473.
    [33]陈建忠, 朱海红, 刘克洲, 等.IL-18重组体联合HBV S基因核酸疫苗免疫小鼠的实验[J].中华传染病杂志, 2002, 20 (3) ∶156-159.
  • 加载中
计量
  • 文章访问数:  2189
  • HTML全文浏览量:  2
  • PDF下载量:  755
  • 被引次数: 0
出版历程
  • 出版日期:  2007-01-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回