Abstract: To study the variation and clinical significance of serum uric acid (UA) in patients with cirrhosis.233 patients with hepatocirrhosis after hepatitis B and 106 healthy subjects were selected.Serum UA, prealbumin (PA) , urea, creatinine (Cr) were measured.The relationship between UA levels renal function and liver function was observed.Serum UA levels of patients with cirrhosis were lower obviously than those of normal controls.And the difference between them was significant (t=2.80, P<0.01) .Serum UA levels of patients with hepatocirrhosis combined with renal function injured increased abnormally.And the difference between this group and normal group was significant (t=4.28, P<0.001) .UA levels in hepatocirrhosis decompensation group were lower than those in hepatocirrhosis compensation group.UA levels of 18 cases in 72 patients with hepatocirrhosis compensation whose renal function was normal decreased, and the ratio 25.0%. UA levels of 44 cases in 111 patients with hepatocirrhosis decompensation whose renal function was normal decreased, and the ratio 39.6%.The difference of ratios between two groups was significant (x2=4.18, P<0.05) .Positive correlation was shown between UA levels and PA levels (r=0.2704, P<0.01) .The results showed that serum UA levels in patients with hepatocirrhosis decompensation whose renal function is normal would decrease, and the decreasing extent would be positive correlated with severity of diseases.So UA might be an useful item for diagnosis, regression and prognosis of hepatocirrhosis.