Abstract: Objective Clinical data from 426 patients suffering from chronic severe hepatitis B were analyzed by logistic regression analysis.Methods It was showed that age, classification of Child-Pugh in hepatic cirrhosis, hematosepsis, hepatorenal syndrome, stages in severe hepatitis and gastrointestinal hemorrhage are independent risk factors related to prognosis;the evaluation equation for assessment of the prognosis was built up by correlative coefficient respectively.Results The scoring system gives different scores between the effective treatment group and ineffective treatment group with statistical significance (P<0.01) when clinical data of patients was used.If we take 0.5 as the limit, the coincidence rate of the effective treatment group is 84.3%, the ineffective treatment group io 95.5%.Conclusion The evaluation equation is very effective in evaluating the prognosis and is valuable in guiding treatment.