c-myb在肝细胞癌组织中的表达及临床意义

张荣贵; 汤正好; 冯洁; 臧国庆; 余永胜

c-myb在肝细胞癌组织中的表达及临床意义

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中图分类号: R735.7
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- 出版日期: 2008-02-20

The expression of c-myb in HCC tissues and clinical significance.

摘要

摘要: 目的研究c-myb基因在HCC组织中的表达,探讨其在HCC发生、发展中的作用及临床意义。方法应用免疫组织化学法检测55例HCC组织、55例癌旁组织、12例肝硬化组织和11例正常肝组织中c-myb蛋白表达情况。结果癌组织相对于正常的肝组织,癌旁组织相对于肝硬化组织,c-myb蛋白的表达明显增高（P=0.000）。结论提示,c-myb过表达是HCC发病中的早期事件,在HCC的发生、发展中可能起重要作用,检测c-myb的表达具有一定的临床意义。
- 肝细胞癌 /
- c-myb /
- 免疫组织化学
Abstract: Objective To study the expression of c-myb in human hepatocelluar carcinoma tissues, we explored its role in the occurrence and development of HCC and clinical significance.Methods The protein expressions of c-myb were detected in 55 HCC tissues, 55 peri-carcinoma tissues, 12 hepatic cirrhosis tissues and 11 normal liver tissues by immunohistochemistry.Results The expression of c-myb protein in HCC tissues compared with normal liver tissues, its expression in peri-carcinoma tissues compared with hepatic cirrhosis tissues were significantly higher (P=0.000) .Conclusion These suggested that overexpression of c-myb gene might be an early accidence in the pathogenesis of HCC, and might play an important role in the occurrence and development of HCC, detecting the expression of c-myb had clinical significance.
- hepatocellular carcinoma /
- c-myb /
- immunohistochemistry

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参考文献(9)

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