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乙型肝炎病毒HBx蛋白与原发性肝癌的关系研究进展

李伟 刘传苗 赵守松

引用本文:
Citation:

乙型肝炎病毒HBx蛋白与原发性肝癌的关系研究进展

基金项目: 

安徽省卫生厅课题(06B080); 

详细信息
  • 中图分类号: R512.6;R735.7

Research funding: 

 

  • [1]Michielsen PP, Francque SM, Dongen JL.Viral hepatitis and hepa-tocellular carcinoma[J].Wor J Sur Onco, 2005, 3 (27) ∶1477-1494.
    [2]Lu XY, Lee M, Tran T, et al.High level expression of apoptosis in-hibitor in hepatoma cell line expressing hepatitis B virus[J].Int JMed Sci, 2005, 2 (1) ∶30-35.
    [3]董菁, 成军, 杨倩.乙型肝炎病毒新开放读码框架的确定及其意义[J].世界华人消化杂志, 2004, 12 (4) ∶757-762.
    [4]Henkler F, Hoare J, Wasseem N, et al.Intracellular localization ofthe hepatitis B virus HBx protein[J].J Gen virol, 2001, 82 (4) ∶871-882.
    [5]Kim KH, Seong BL.Pro-apoptotic function of HBV X protein ismediated by interaction with c-FLIP and enhancement of death-in-ducing signal[J].EMBO J, 2003, 22 (9) ∶2104-2116.
    [6]Marusawa H, Matsuzawa S, Welsh K, et al.HBXIP functions as acofactor of survivin in apoptosis suppression[J].EMBO J, 2003, 22 (11) ∶2729-2740。
    [7]Tang H, Delgermaa L, Huang F, et al.The transcriptional transac-tion function of HBx protein is important for its augmentation role inHepatitis B virus replication[J].J Virol, 2005, 79 (9) ∶5548-5556.
    [8]Leon B, Taylor L, Vargas M, et al.HBx M130K and V131I (T-A) mutations in HBVgenotype F during a follow-up study in chron-ic carriers[J].Vir J, 2005, 2 (60) ∶1743-1753.
    [9]Kuang SY, Jackson PE, Wang JB, et al.Specific mutations of hepa-titis B virus in plasma predict liver cancer development[J].PNAS, 2004, 1010 (10) ∶3575-3580.
    [10]Li H, Chi CY, Lee S, et al.The mitogenic function of hepatitis Bvirus protein resides within amino acids51-140 and is modulated byN-and C-terminal regulatory regions[J].J Virol, 2006, 80 (21) ∶10554-10564.
    [11]Madden CR, Finegold MJ, Slagle BL.Altered DNAmutation spec-trum in aflatoxin B1-treated transgenic mice that express the hepati-tis B virus X protein[J].J Virol, 2002, 76 (22) ∶11770-11774.
    [12]Bouchard MJ, Sehneider RJ.The Enigmatic X Gene of Hepatitis Bvirus[J].J Virol, 2004, 78 (23) ∶12725-12734.
    [13]Rahmani Z, Huh KW, Lasher R, et al.Hepatitis B virus X proteincolocalizes to mitochondria with a human voltage-dependent anionchannel HVDAC3, and alters its transmembrane potential[J].J Vir-ol, 2000, 74 (6) ∶2840-2846.
    [14]Bergametti F, Sitterlin D, Transy C.Turnover of hepatitis B virus Xprotein is regulated by damaged DNA-binding complex[J].J Virol, 2002, 76 (13) ∶6495-6501.
    [15]Lwa SH, Chen WN.Hepatitis B virus X protein interacts withβ5[J].Vir J, 2005, 2 (76) ∶1743-1750.
    [16]Doria M, Klein N, Lucito R, et al.The hepatitis B virus HBx pro-tein is a dual specificity cytoplasmic activator of Ras and nuclear acti-vator of transcription factors[J].EMBO J, 1995, 14 (19) ∶4747-4757.
    [17]Tarn C, Lee S, Hu Y, et al.Hepatitis B virus X protein differenti-ally activates RAS-RAF-MAPKand JNKpathways in X-transfor-ming versus non-transforming AML 12 hepatocytes[J].J BiolChem, 2001, 276 (37) ∶34671-34680.
    [18]刘亮明, 罗文, 刘晶美, 等.HBx在原发性肝癌发病中的作用及其生物治疗策略[J].世界华人消化杂志, 2005, 13 (4) ∶432-439.
    [19]Sansal I, Sellers WR.The biology and clinical relevance of thePTEN tumor suppressor pathway[J].J Clin Onco, 2004, 22∶2954-2963.
    [20]Chen BC, Wu WT, Ho FM, et al.Inhibition of interleukin-lbeta-induced NF-kappaB activation by calcium/calmodulin-depend-ent protein kinase kinase occurs through Akt activation associatedwith interleukin-1 receptor-associated kinase phosphorylation anduncoupling of MyD88[J].J Biol Chem, 2002, 277 (27) ∶24169-24179.
    [21]Madden CR, Finegold MJ, Slagle BL.Hepatitis B virus x proteinacts as a tumor promoter in development of diethylnitrosamine-in-duced preneoplastic lesions[J].J Virol, 2001, 75 (8) ∶3851-3858.
    [22]Sakurai T, Maeda S, Chang L, et al.Loss of hepatic NF-KB ac-tivity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation[J].PNAS, 2006, 103 (28) ∶10544-10551.
    [23]Nijhara R, Jana SS, Goswami SK, et al.Sustained Activation ofmitogen-activated protein kinases and activator protein1 by the hep-atitis B virus x protein in mouse hepatocytes in vivo[J].J Virol, 2001, 75 (21) ∶10348-10358.
    [24]Bouchard MJ, Wang L, Schneider R.Activation of focal adesionkinase by hepatitis B virus HBx protein:multiple functions in viralreplication[J].J Virol, 2006, 80 (9) ∶4406-4414.
    [25]Barone M, Spano D, Apolito MD, et al.Gene expression analysisin HBV transgenic mouse liver:a model to study early events relatedto hepatocarcinogenesis[J].Mol Med, 2006, 12 (4-6) ∶115-123.
    [26]Elmore L W, Hancock A R, Chang SF, et al.Hepatitis B virus Xprotein and p53 tumor suppressor interactions in the modulation ofapoptosis[J].Proc Natl Acad Sci, 1997, 94∶14707-14712.
    [27]Pan J, Duan LX, Sun BS, et al.Hepatitis B virus X protein pro-tects against anti-Fas-mediated apoptosis in human liver cells byinducing NF-kB[J].J Gen Virol, 2001, 82∶171-182.
    [28]Shih WL, Kuo ML, Chuang SE, et al.Hepatitis B virus X proteininhibits transforming growth factor-β-induced apoptosis throughthe activation of phosphatidylinositol 3-kinase pathway[J].J BiolChem, 2000, 275 (33) ∶25858-25864.
    [29]Shirakata Y, Koike K.Hepatitis B virus X protein induces celldeath by causing loss of mitochondrial membrane potential[J].J BiolChem, 2003, 278 (24) ∶22071-22078.
    [30]Forgues M, Difilippantonio MJ, Linke SP, et al.Involvement ofCrml in hepatitis B virus X protein-induced aberrant centriole repli-cation and abnormal mitotic spindles[J].Mol Cell Biol, 2003, 23 (15) ∶5282-5292.
    [31]Yun C, Cho H, KimSJ, et al.Mitotic aberration coupled with cen-trosome amplification is induced by hepatitis B virus X oncoproteinvia the ras-mitogen-activated protein/extracellular signal-regula-ted kinase-mitogen-actvated protein pathway[J].Mol CancerRes, 2004, 2∶159-169.
    [32]Bouchard M, Giannakopoulos S, Wang EH, et al.Hepatitis B virusHBx protein activation of cyclin A-cyclin dependent kinase 2 com-plexes and G1 transit via a Src kinase pathway[J].J Virol, 2001, 75 (9) ∶4247-4257.
    [33]Park US, Park SK, Lee YI, et al.Hepatitis B virus X protein up-regulates the expression of p21 wafl/cipl and prolongs G1-S transi-tion via a p53-independent pathway in human hepatoma cells[J].Oncogene, 2000, 19∶3384-3394.
    [34]Han HJ, Jung EY, Lee WJ, et al.Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virusX protein and hepatitis C virus core protein[J].FEBS letters, 2002, 518∶169-172.
    [35]Lee S, Tarn C, Wang WH, et al.Hepatitis B virus X protein dif-ferentially regulates cell cycle progression in X-transforming versusnontransforming hepatocyte (AML12) cell lines[J].J Biol Chem, 2002, 277 (10) ∶8730-8740.
    [36]Lara-Pezzi E, Gomez-Gaviro MV, Galvez BG, et al.The hepa-titis B virus X protein promotes tumor cell invasion by inducing mem-brane-type matrix metalloproteinase-1 and cyclooxygenase-2 ex-pression[J].J Clin Inv, 2002, 110 (12) ∶1831-1838.
    [37]Chan CF, Yau TO, Jin DY, et al.Evaluation of nuclear factor-kappa B, urokinase-type plasminogen activator, and HBx and theirclinicopathological significance in hepatocellular carcinoma[J].ClinCancer Res, 2004, 10∶4140-4149.
    [38]Tufan NL, Lian ZR, Liu J, et al.Hepatitis Bx antigen stimulatesexpression of a novel cellular gene, URG4, that promotes hepatocel-lular growth and survival[J].Neoplasia, 2002, 4 (4) ∶355-368.
    [39]Lian ZR, Liu J, Li L, et al.Upregulated expression of a uniquegene by hepatitis Bx antigen promotes hepatocellular growth and tu-morigenesis[J].Neoplasia, 2003, 5 (3) ∶229-244.
    [40]Hwang GY, Lin CY, Huang LM, et al.Detection of the hepatitis Bvirus X protein (HBx) antigen and anti-HBx antibodies in cases ofhuman hepatocellular carcinoma[J].J Clin Micro, 2003, 41 (12) ∶5598-5603.
    [41]Tralhao JG, Roudier J, Morosan S, et al.Paracrine in vivo inhibi-tory effects of hepatitis B virus X protein (HBx) on liver cell prolifer-ation:An alternative mechanism of HBx-related pathogenesis[J].PNAS, 2002, 99 (1) ∶6991-6996.
    [42]Han JQ, Ding LH, Yuan B, et al.Hepatitis B virus X protein andthe estrogen receptor variant lacking exon 5 inhibit estrogen receptorsignaling in hepatoma cells[J].Nucleic Acids Res, 2006, 34 (10) ∶3095-3106.
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