HLA-A等位基因多态性对慢性乙肝病情的影响研究

张丰晓; 吴继周; 郑奕; 李国坚; 陈茂伟; 吴健林; 韦颖华

HLA-A等位基因多态性对慢性乙肝病情的影响研究

基金项目:

广西卫生厅课题(Z2005062)；广西自然科学基金课题(桂科自0728159)；

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中图分类号: R512.62;R450
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出版历程
- 出版日期: 2008-06-20

Study on the effects of alleles polymorphisms of HLA-A on the state of prognosis of chronic hepatitis B

Research funding:

摘要

摘要: 目的探讨HLA-A等位基因多态性对慢性病毒性乙型肝炎病情的影响。方法以慢性病毒性乙型肝炎、肝炎肝硬化、慢性乙肝重型患者及正常人作为研究对象,应用聚合酶链反应/序列特异性引物技术（PCR-SSP）对研究对象的HLA-A等位基因多态性进行分析,研究等位基因HLA-A*31、HLA-A*02、HLA-A*11与慢性病毒性乙型肝炎、肝炎肝硬化、慢性乙肝重型病情的关系。结果与对照组相比,HLA-A*31、HLA-A*02、HLA-A*11三个等位基因在慢性病毒性乙型肝炎、肝炎肝硬化、慢性乙肝重型三组间的分布频率均无显著性差别（P>0.05）。结论结果提示:HLA-A*31、HLA-A*2、HLA-A*11三个等位基因对慢性病毒性乙型肝炎、肝炎肝硬化、慢性乙肝重型的病情似无明显影响。
- HLA-A /
- 等位基因多态性 /
- PCR-SSP /
- 慢性乙肝
Abstract: Objective To study on the effects of alleles polymorphisms of HLA-A on the state of prognosis of chronic hepatitis B.Methods Subjects were the patients with chronic hepatitis B, liver cirrhosis, chronic severe hepatitis B and healthy controls from Guangxi province.The Polymerase Chain Reaction-Sequence Specific Primer (PCR-SSP) technique was adopted to investigate the alleles polymorphisms of HLA-A.Results There was no significant difference among the four groups in frequency of HLA-A31, HLA-A02, HLA-A11.Conclusion It might be no suggested that the alleles of HLA-A31, HLA-A02, HLA-A11 have effects on the development of chronic hepatitis B, liver cirrhosis, chronic severe hepatitis B.
- HLA-A /
- Alleles Polymorphisms /
- PCR-SSP /
- Chronic hepatitis B

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参考文献(7)

[1]中华医学会.病毒性肝炎的诊断标准[J].中西医结合肝病杂志, 2001, 11 (1) :56-60.

[2]Bunce M, O'Neil CM, Barnard MC, et al.Phototyping:comprehe-nsive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5&DOB1by PCR with144primer mixes utilizing sequence specific Primers (PCR-SSP) [J].Tissue Antigens, 1995, 46 (5) :355-367.

[3]李长缨, 赵林, 李建忠, 等.中国北方汉族人HLA-Ⅰ, Ⅱ类基因与HBV水平感染及预后相关研究[J].中国输血杂志, 2005, 18 (6) :459-463.

[4]Chloe L, Thio DL, Thomas PK, et al.Comprehensive analysis of classⅠand class-ⅡHLA antigens and chronic hepatitis B virus infection[J].Virology, 2003, 77:12083-12087.

[5]Missale G, Redeker A, Person J, et al.HLA-A31-and HLA-Aw68-restricted cytotoxic Tcell responses to a single hepatitis B vi-rus nucleocapsid epitope during acute viral hepatitis[J].Exp Med.1993, 3 (177) :751-753.

[6]Franke ED, Hoffinan SL, Sacci JB, et al.Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoelii sporozoites[J].Vaccine, 1999, 17:1201-1205.

[7]周琼云, 李执如, 廖耘, 等.四川汉族基因频率和显著连锁不平衡单型分析[J].国际检验医学杂志, 2006, 27 (1) :86-88.

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