Abstract: Objective Purpose right native Tibetan hepatitis B virus (HBV) genotype and clinical characteristics were analyzed.Methods Among 78 cases of patients with the native Tibetan HBV gene type, Quantitative analysis of hepatitis B virus DNA and liver function, two pairs of semi-HB, liver fibrosis, AFP, CEA, a B-ultrasonic testing of abdomen, and clinical characteristics were analyzed.Results Native Tibetan hepatitis B genotypes in patients with hepatitis B virus mainly B-and C-type, 78 cases of patients with B-41, C-37, B-and C-type pose no significant difference.C-type HBV DNA in patients with quantitative, the indicators of liver function, liver fibrosis, AFP, HBeAg positive rate, CEA-positive rate, the incidence of cirrhosis, liver cancer incidence, splenomegaly incidence was significantly higher than that in patients with type B (P<0.05) .Conclusion Native Tibetan HBV genotype mainly B, and C-type, C-type patients with cirrhosis, the incidence of liver cancer and liver fibrosis and liver dysfunction significantly higher than in patients with type B, the C in clinical right-native Tibetan hepatitis B patients should strengthen targeted prevention.