维生素D受体基因多态性与慢性乙型肝炎的相关性

秦华; 陈红

维生素D受体基因多态性与慢性乙型肝炎的相关性

秦华,
陈红

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中图分类号: R512.62;R450
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出版历程
- 出版日期: 2009-01-20

Study on association between vitamin D receptor gene polymorphisms and the chronic hepatitis B.

Qin Hua,
Chen Hong

摘要

摘要: 目的探讨维生素D受体(VDR)基因多态性与慢性乙型肝炎的相关性。方法以53例慢性乙肝患者和56例健康人为研究对象,应用聚合酶链反应—限制性片段长度多态性方法分析VDR基因FokI和BsmI酶切位点的多态性。两组间基因型比较采用x2检验。结果53例慢性乙肝患者中,BB、Bb、bb基因型频率分别为9.4%、20.8%、69.8%,其中BB基因型频率高于正常对照组,差异有统计学意义(P<0.05)。B等位基因频率在慢乙肝组为19.8%显著高于正常对照组8.9%(P<0.05)。病例组中FF、Ff、ff基因型频率分别为32.1%、52.8%、15.1%,与正常对照组无统计学差异。F等位基因频率在慢乙肝组为58.5%,与正常对照组差异无统计学意义。结论VDR基因多态性与HBV感染有关,特别是BsmI酶切位点多态性可增加慢性HBV感染。
- 维生素D受体(VDR) /
- 慢性乙型肝炎 /
- 基因多态性
Abstract: Objective To investigate whether the vitamin D receptor gene polymorphisms are associated with the chronic hepatitis B.Methods 53 patients and 56 healthy peoples were studied.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphisms of FokI locus and BsmI locus of VDR gene.The comparision of frequence of genotype between the patients and controls were analyzed by Chi-square test.Results The BB genotype frequency in patients group was higher than that in normal control group (9.4% vs 0) , and there was a significant correlation (P<0.05) .The frequence of B allele in patients group was 19.8%, higher than that 8.9% in control group (P<0.05) .The frequence of genotype of FF、Ff and ff was 32.1%、52.8% and 15.1% in patients, and there was no significant correlation between patients and normal control group.At the sametime, the allele frequency of F in the chronic hepatitis B group was higher than that in normal control group (58.8% vs 50.9%) , but there was no significant correlation between them.Conclusion VDR gene polymorphisms may be related with chronic HBV infection, especially the allele B of BsmI locus may be an important factor related to the chronic HBV infection.
- vitamin D receptor (VDR) /
- chronic hepatitis B /
- gene polymorphism

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参考文献(8)

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