中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝纤维化形成机制的研究进展

丁宁

引用本文:
Citation:

肝纤维化形成机制的研究进展

详细信息
  • 中图分类号: R575.2

Advances in the pathogenesis of liver fibrosis


  • [1]Friedman SL.Cytokines and fibrogenesis[J].Semin Liver Dis, 1999, 19 (2) ∶129-140.
    [2]王萍.血小板衍生生长因子与肝纤维化[J].国外医学.消化疾病分册, 2000, 20 (1) ∶40-43.
    [3]Boesen CC, Radaev S, Motyka SA, et al.The 1.1 A crystal struc-ture of human TGF-beta type II receptor ligand bindingdomain[J].Structure, 2002, 10 (7) ∶913-919.
    [4]Schuster N, Krieglstein K.Mechanisms of TGF-beta-mediatedapoptosis[J].Cell Tissue Res, 2002, 307 (1) ∶1-14.
    [5]Palmer EM, Beilfuss BA, Nagai T, et al.Human helper Tcell acti-vation and differentiation is suppressed by porcine small intestinalsubmucosa[J].Tissue Eng, 2002, 8 (5) ∶893-900.
    [6]Hodge S, Hodge G, Flower R, et al.Up-regulation of productionof TGF-beta and IL-4 and down-regulation of IL-6 by apoptotichuman bronchial epithelial cells[J].Imnaunol Cell Biol, 2002, 80 (6) ∶537-543.
    [7]Paradis H, Liu CY, Saika S, et al.Tubedown-1 in remodeling ofthe developing vitreal vasculature in vivo and regulation of capillaryoutgrowth in vitro[J].Dev Biol, 2002, 249 (1) ∶140-155.
    [8]Gressner AM, Weiskirchen R.Modern pathogenetic concepts of liverfibrosis suggest stellate cells and TGF-beta as major players andtherapeutic targets[J].Cell Mol Med, 2006, 10 (1) ∶76-99.
    [9]ZHAO Jun-fang, LIU Cheng, LIU Cheng-hai.TGF-βintracellular signal transduction and Smads protein[J].Chinesejournal of pathophysiology, 2002, 18 (3) ∶321-325.
    [10]梁志清, 何振平.贮脂细胞TGF-β1受体反义基因转移及对细胞外基质合成的抑制作用[J].中华医学杂志, 1998, 78∶850-852.
    [11]Laping NJ, Grygielko E, Mathur A, et al.Inhibition of transforminggrowth factor (TGF) -beta1-induced extracellular matrix with anovel inhibitor of the TGF-beta type I receptor kinase activity:SB-431542[J].Mol Pharmacol, 2002, 62, (1) ∶58-64.
    [12]Robert A B, piek E, Bottinger EP, et al.Is Smad3 a major playerin signal transduction pathways leading to fibrogenesis[J]?Chest, 2001, 120 (1 Suppl) ∶43S-47S.
    [13]de Caestecker MP, Paks WT, Frank CJ, et al.Smad2 transducescommon signals from receptor serine-threonine and tyrosinekinases[J].Genes Dev, 1998, 12 (11) ∶1587-1592.
    [14]Moustakas A, Souchelnytskyi S, Heldin CH.Smad regulation inTGF-beta signal transduction[J].Journal of Cell Science, 2001, 114 (24) ∶4359-4369.
    [15]Correia JJ, Chacko B M, Lam S S, et al.Sedimentation studies re-veal a direct role of phosphorylation in Smad3:Smad4 homo-andhetero-trimerization[J].Biochem, 2001, 40 (5) ∶1473-1482.
    [16]Wiercinska E, Wickert L, Denecke B, et al.Id1 is a critical media-tor in TGF-beta-induced transdifferentiation of rat hepatic stellatecell[J].Hepatology, 2006, 43 (5) ∶1032-41.
    [17]LI Guang-ming, SHI Yi, LI Ding-guo, et al.Effect of small inter-fering DNA targeting connective tissue growth factor on the synthesisand secretion of extracellular matrix in hepatic stellate cells[J].Zhonghua Gan Zang Bing Za Zhi, 2004, 12 (9) 526-9.
    [18]Holmes A, Abraham DJ, Sa S, et al.CTGF and SMADs, mainte-nance of scleroderma phenotype is independent of SMADsignaling[J].J Biol Chem, 2001, 276 (14) ∶10594-10601.
    [19]彭小东, 戴立里.结缔组织生长因子与肝纤维化的研究进展[J].胃肠病学与肝病学杂志, 2005, 14 (4) ∶425-427.
    [20]Saxena N K, Titus MA, Ding X, et al.Leptin as a novel profibro-genic cytokine in hepatic stellate cells:mitogenesis and inhibition ofapoptosis mediated by extracellular regulated kinase (ErK) and Aktphosphory lation[J].FASEB J, 2004, 18 (13) ∶1612-1614.
    [21]Cao Q, Mak K M, Lieber C S, et al.Leptin enhances alpha1 (I) collagen gene expression in LX-2 human hepatic stellate cellsthrough JAK-mediated H2O2-dependent MAPK pathways[J].JCell Biochem, 2006, 97 (1) ∶188-197.
    [22]何生松, 黄化方.酒精性肝硬化患者体外单核细胞肿瘤坏死因子受体的表达[J].中华内科杂志, 1997, 36 (8) ∶526-528.
    [23]Rockey DC, Malter JJ, Jarnagn WR, et al.Inhibition of rat hepaticlipocyte activation in culture by interferon-gamma[J].Hepatology, 1992, 16 (3) ∶776-784.
    [24]Napoli T, Bioshop GA, Meaughan GW.luereased interhepatic mes-sager RNA expereaaion of interleukin 2, 6 and 8in humancirrhosia[J].Gastroenology, 1994, 107 (3) ∶789-798.
    [25]王润平, 刘成, 刘平.肝纤维化形成过程中肝星状细胞激活的旁分泌机制[J].中华肝脏病杂志, 1997, 5 (3) ∶184-186.
    [26]Kura Y, Ohsaw AM, Shirain, et al.Expression of angiotensinⅡtype1 recetor in human cirrhotic liver Its relation to fibrosis and potalhypertension[J].Hepatol Res, 2005, 32 (3) ∶107-116.
    [27]Yang L, Bataller R, Dulyx J, et al.Attenuated hepatic inflammationand fibrosis in angiotensin type 1 a receptor deficient mice[J].JHepatol, 2005, 43 (2) ∶317-323.
    [28]Knittel T, Mehde M, Grundmann A, et al.Expression of matrixmetalloproteinases and their inhibitors during hepatic tissue repair inthe rat[J〗.Histochem Cell Biol, 2000, 113 (6) ∶443-453.
    [29]Koulentaki M, Valatas V, Xidakis K, et al.Matrix metalloprotein-ases and their inhibitors in acute viral hepatitis[J].J Viral Hepat, 2002, 9 (3) ∶189-193.
    [30]Woessner JF Jr.MMPs and TIMPs-an historical perspective[J].Mol Biotechnol, 2002 (1) ∶33-49.
    [31]Rippe RA.Life or death:the fate of the hepatic stellate cell follow-ing hepatic injury[J].Hepatology, 1998, 27 (5) ∶1447-1448.
  • 加载中
计量
  • 文章访问数:  3340
  • HTML全文浏览量:  5
  • PDF下载量:  979
  • 被引次数: 0
出版历程
  • 出版日期:  2009-01-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回