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摘要: 目的观察大于40岁ALT正常慢性HBV感染者的肝组织纤维化分期的情况。方法选择64例慢性HBV感染者,检测血清肝功能、HBeAg、HBVDNA、进行肝脏活检,提供肝组织纤维化分期情况。结果年龄大于40岁ALT正常慢性HBV感染者肝组织73.44%有2期及以上的纤维化。肝纤维分期与Ⅲ型前胶原、透明质酸具有相关性(P<0.05),HBVDNA、HBeAg与肝组织纤维化无相关性(P>0.05)。结论大于40岁ALT正常的HBV慢性感染者有3/4肝组织纤维分期在2期以上,应关注其抗纤维化治疗。Abstract: Objective To analyze the stages of liver fibrosis in patients aged older than 40 with normal ALT.Methods 84 patients with chronic HBV infected were investigated in this study.Liver function, HBeAg, HBVDNA, serum liver fibrosis indexes were tested.And liver biopsy was taken in all the patients and the tissues were stained with HE and Masson.Results 73.4% patients were at fibrosis stage 2-4.The serum fibrosis indexes correlated with the fibrosis stage of liver histology.While the levels of HBeAg and HBVDNA didn't correlate with the severity of liver fibrosis.Conclusion Liver fibrosis of patients older than 40-year-old should be analyzed synthetically with many clinical indexes.These patients should be administered with antifibrosis therapy to prevent the progression of liver cirrhosis.
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Key words:
- HBVDNA /
- ALT /
- HBeAg /
- hepatic histopathology
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[1] 中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8;324-329. [2]Pratt DS, Kalplan MM.Evaluatinon of abnormal liver-enzymeresultsin asymptomatic patients[J].N Engl J Med, 2000, 342 (17) ∶1266-1271. [3]Craxi A, Almasio P.Diagnostic approach to liver enzymeelevation[J].Hepatol, 1996, 25 (Suppl) ∶S47-S51. [4]Wang C, Deubner H, Shuhart M, et al.High prevalence of significantfibrosis in patients with immunotolerance to chronic hepatitis B infec-tion[J].Hepatology, 2005, 42 (Suppl 1) ∶537A. [5]颂鸿硕, 石爽, 庄辉.ALT水平正常的慢性乙型肝炎研究进展[J].传染病信息, 2007, 20 (1) , 7-8. [6]Keeffe EB, Dieterich DT, Han SH, et al Treatment algorithm for themanagement of chronic hepatitis B virus infection in the UnitedStates[J].Clin Gastroenterol Hepatol, 2004, 2 (2) ∶8 7-106. [7]Keeffe EB, Dieterich DT, Han SH, et al.Treatent algorithm for themanagement of chronic hepatitis B virus infection in the UnitedStates:an update[J].Clin Gastroenterol Hepatol, 2006, 4 (8) ∶936-962. [8]Chu CM, Hung SJ, Lin J, et al.Natural history of hepatitis B e anti-gen to antibody seroconversion in patients with nomal serum amin-otransferase levels[J].Am J Med, 2004, 116 (12) ∶829 834. [9]Brunetto MR, Oliveri F, Coco B, .Outcome of anti-HBe positivechronic hepatitis B in alpha-interferon treated and untreated pa-tients:a long term cohort study[J].Hepatol, 2002, 36∶263-270. [10]王建军, 成军.乙型肝炎病毒HBeAg的生物学作用[J].胃肠病学和肝病学杂志, 2004, 13 (1) ∶76-78. -
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