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摘要: 目的探讨肝硬化与肝癌患者血浆氨基酸变化及其临床意义。方法用日立835氨基酸分析仪对46例肝硬化患者和44例肝癌患者血浆氨基酸进行测定。方法用日立835氨基酸分析仪对46例肝硬化患者和44例肝癌患者血浆氨基酸进行测定。结果肝硬化时血浆谷氨酸、胱氨酸、蛋氨酸、酪氨酸显著升高(P<0.01),苏氨酸、苯丙氨酸明显升高(P<0.05);肝癌时血浆苏氨酸、酪氨酸、苯丙氨酸显著升高(P<0.01),丝氨酸明显升高(P<0.05);两组中BCAA/AAA(支链氨基酸/芳香族氨基酸)比值均较正常对照组显著降低(P<0.01),缬氨酸、亮氨酸较正常对照组明显降低(P<0.05)。说明以上血浆氨基酸分析与对照组之间的差异有统计学意义。结论血浆氨基酸分析对肝硬化与肝癌诊断和治疗有一定指导意义。Abstract: Objective To explore the change of serum amino acid serum in patients with liver cirrhosis and liver cancer, and its significance.Methods The serum amino acids of 46 patients with liver cirrhosis and 44 patients with liver cancer were examined with analyzer of Hitachi 835.Results In the case of patients with liver cirrhosis, the levels of glutamic acid, cystine, methionine and tyrosine in serum were significantly increased (P<0.01) , while, the level of phenylalanine in serum was obviously increased (P<0.05) .When it came to patients with liver cancer, the levels of serum threonine, tyrosine and phenylalanine were significantly increased (P<0.01) , the level of serum serine was obviously higher (P<0.05) .The level of BCAA/AAA (branched chain amino acids/aromatic amino acid) in the two groups was lower than that in the normal control group (P<0.01) .The levels of serum valine and leucine were lower than those in the normal control group (P<0.05) .Conclusion Analyzing the levels of serum amino acids has a certain significance for diagnosing and treating patients with liver cirrhosis and liver cancer.
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Key words:
- Amino acids /
- liver cirrhosis /
- liver cancer
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[1]Marchesini G, Bianchi G, Brizi M, et a1.Nutritional treatment withbranched-chain amiro acids in advanced liver cirrhosis[J].JGestroenterol, 2OOO, 35 (Suppl) 12∶7-l2. [2]Kawarnura Yasui N, Kaito M, Fujita N, et a1.Evaluating response tonutritionaltherapy using the branched—chain amiro acid/tyrosine ra-tio in patients with chrunie liver disease[J].J Clin Lab Anal, 1999, 13 (1) ∶31-34. [3]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) ∶56-62. [4] 原发性肝癌的临床诊断与分期标准[s].中国抗癌协会肝癌专业委员会第八届全国肝癌学术会议.广州, 2001∶9. [5]David Z, Thomas BD.Hepatology[M].A Textbook of Liver Disease.3rd ed.Saunders, 1996∶605-614. -
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