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摘要: 目的观察干扰素联合拉米夫定治疗慢性乙型肝炎患者的疗效。方法90例慢性乙型肝炎患者随机分为两组:42例干扰素α-2b联合拉米夫定治疗组,48例单用拉米夫定对照组:观察比较两组患者治疗后HBVDNA水平,乙型肝炎病毒血清标志物及肝功能变化。结果治疗结束时,联合治疗组患者血清中HBVDNA阴性率和肝功能复常率明显高于单用拉米夫定治疗组,联合治疗组完全应答率40.5%,优于单用拉米夫定治疗组22.9%（P<0.01）;随访24周联合治疗组的上述指标仍高于拉米夫定对照组（P<0.05）。结论干扰素α-2b联合拉米夫定治疗慢性乙型肝炎,可提高HBeAg/抗HBe血清转换率及综合应答率,并可防止或减少YMDD变异的发生。Abstract: Objective To inderify the efficacy of combination treatment of Lamivudine and INF-α 2b in patients with chronic hepatitis B.Methods Ninety patients with CHB were divided into two groups casually.The treating group (n=42) was treated with INF-α 2b combined with Lamivudine.While the control group (n=48) was treated with Lamivudine only.HBVDNA, liver function indexes and HBeAg/HBeAb conversion ratio in the plasma of those patients were observed.Results The negative rate of serum HBVDNA and liver function indexes in treating group were obvious better than those in control group at the end of 48 weeks' treatment.The complete response rate was 40.5% in treating group, which was higher than that in control group (22.9%) (P<0.01) .After 24 weeks follow up, those were still higher in the treating group than in control group.Conclusion Combination of Lamivudine and INF-α 2b in the treatment of patients with CHB can get a better effect, which might improve complete response and decrease YMDD mutation.
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Key words:
- chronic hepatitis B /
- Interferon-α 2b /
- Lamivudine /
- drug combination.
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