内皮素与肝脏疾病

杨律; 王启之; 张晨光

内皮素与肝脏疾病

蚌埠医学院第一附属医院消化内科

基金项目:

安徽省教育厅自然科学研究资助项目(2000JL159)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2009-04-20

Research funding:

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参考文献(19)

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[3]Moridaira K, Morrissey J, Fitzgerald M, et al.ACE inhibition in-creases expression of the ETBreceptor in kidneys of mice with unilat-eral obstruction[J].Am J Physiol Renal Physiol, 2003, 284 (1) ∶F209-217.

[4]Tieche S, De Gottardi A, Kappeler A, et al.Over expression of en-dothelin-1 in bile duct ligated rats:correlation with activation of he-patic stellate cells and portal pressure[J].J Hepatol, 2001, 34 (1) ∶38-45.

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[6]Ikura Y, Ohsawa M, Naruko T, et al.Expression of the hepatic en-dothelin system in human cirrhotic livers[J].J Pathol, 2004, 204 (3) ∶304-310.

[7]夏金荣.肝星状细胞与肝纤维化[J].临床荟萃, 2006, 21 (4) ∶298.

[8]Yang C, Zeisheng M, Mosterman B, et al.Iiver fibrosis:insights intomigration of hepatic stellate cells in response to extracellular matrixand growth factors[J].Gastroenterology, 2003, 124 (1) ∶147-159.

[9]Reeves HL, Friedman SL.Activation of hepatic stellate cells-a keyissue in liver fibrosis[J].Front Biosci, 2002, 7∶d808-d826.

[10]Masahiko K, Michael B, Anja K, et al.Endothelin-1 enhancesfibrogenic gene expression, but does not promote DNA synthesis orapoptosis in hepatic stellate cells[J].Comparative Hepatology, 2006, 5∶5.

[11]Watanabe N, Takashimizu S, Nishizaki Y, et al.An endothelin Are-ceptor antagonist induces dilatation of sinusoidal endothelial fenes-trae:implications for endothelin-1 in hepatic microcirculation[J].J Gastroenterol, 2007, 42 (9) ∶775-782.

[12]Shibamoto T, Kamikado C, Koyama S.Increased sinusoidal resist-ance is responsible for the basal state and endothelin-induced veno-constriction in perfused cirrhotic rat liver[J].Pflugers Arch, 2008, 456 (3) ∶467-477.

[13]Ghandhi CR, Stephenson K, Olson MS.Endothelin, a potent pep-tide agonist in the liver[J].J Biol Chem, 1990, 265 (29) ∶17432-17435.

[14]Kuroda N, Yamanaka J, Okada T, et al.Hepatic effects of influxedendothelin-1 from portal vein:in situ portal vein infusion model u-sing dogs[J].J Hepatobiliary Pancreat Surg, 2006, 13 (2) ∶160-166.

[15]王启之, 郑玉宝, 吴炎, 等.一氧化氮及内皮素在肝硬化患者肝损害中的作用及对肝门脉血流动力学的影响[J].蚌埠医学院学报, 2007, 32 (1) ∶7-9.

[16]Nagasue N, Dhar DK, Yamanoi A, et al.Production and release ofendothelin-1from the gut and spleen in portal hypertension due tocirrhosis[J].J Hepatology, 2000, 31 (5) ∶1107-1114.

[17]Tran Duc AT, Schwab AJ, Simard A, et al.Reduction in hepaticendothelin-1clearance in cirrhosis[J].Clin Sci, 2003, 105 (2) ∶227-234.

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[19]Fukui R, Nishimori H, Hata F, et al.Inhibitory effect of endothe-lin A receptor blockade on tumor growth and liver metastasis of a hu-man gastric cancer cell line[J].Gastric Cancer, 2007, 10 (2) ∶123-8.

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