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摘要: 目的观察肿瘤坏死因子相关凋亡诱导配体（TRAIL）在HBV感染所致免疫损伤中的作用。方法选择慢性乙肝患者（CHB）20例,乙肝病毒携带者（ASC）20例,正常健康者10例,ELISA检测其血清sTRAIL水平,同时检测血清IFN-γ和ALT水平。结果ASC组和CHB组sTRAIL水平明显高于正常健康组(P（0.01）,且CHB组高于ASC组(P（0.01）;CHB组IFN-γ水平明显高于正常组和ASC组(P（0.05）,而正常组和ASC组之间差异无统计学意义(P（0.05）。在CHB中sTRAIL水平与ALT的值呈正相关(P（0.01）。结论TRAIL在IFN-γ的协同作用下,参与了HBV感染所致的免疫损伤,在HBV感染所致免疫损伤中起重要作用。Abstract: Objective To explore the effect of TRAIL on the immunolesion in patientswith chronic hepatitis B.Methods The serum level of sTRAIL of 20 patients with chronic hepatitis B (CHB) and 20 patients with asymptomatic HBV carriage (ASC) and 10 healthy people was determined by specific-ELISA, while the serum level of IFN-γ and ALT was determined.Results The level of TRAIL of CHB group and ASC group were higher than that of normal group (P﹤0.01) , while the level of TRAIL of CHB group were higher than that of ASC (P﹤0.01) .The level of IFN-γ of CHB group were higher than that of healthy people and ASC (P﹤0.05) .In the CHB group, the expression level of sTRAIL was positively related to the ALT value (P﹤0.01) .Conclusion With the cooperation of IFN-γ, TRAIL probably plays a key role on the immunolesion in patients with chronic hepatitis B.
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Key words:
- chronic hepatitis B /
- immunolesion /
- TRAIL /
- IFN-γ
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[1]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) :324-329. [2]Thorburn A.Tumor necrosis factor-related apoptosis-inducing lig-and (TRAIL) pathway signaling[J].J Thorac Oncol, 2007, 2 (6) :461-465. [3]Falschlehner C, Emmerich CH, Gerlach B, et al.TRAILsignalling:decisions between life and death[J].Int J Biochem Cell Biol, 2007, 39 (7-8) :1462-1475. [4]Ghavami S, Hashemi M, Kadkhoda K, et al.Apoptosis in liver dis-eases--detection and therapeutic applications[J].Med Sci Monit, 2005, 11 (11) :RA337-345. [5]Mundt B, Kuhnel F, Zender L, et al.Involvement of TRAIL and its receptors in viral hepatitis[J].FASEB J, 2003, 17:94-96. [6]Shin EC, Ahn JM, Kim CH, et al.IFN-gamma iduces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotie pathway[J].Int J Cancer, 2001, 93:262-268. -
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