Abstract: Objective To observe the curative effect of continuous ven-venous hemofiltration on gravis type hepatitis combined with hepatic encephalopathy patient.Methods 32 patients with gravis type hepatitis combined with hepatic encephalopathy patient were divided into 2 groups, Therapy group:medical combined therapy+ CVVH.Control group:medical combined therapy.Liver renal function, blood ammonia, TNF and IL-6 were detected before and after therapy.Results The awake rate of therapy group and control group were 75.0% and 31.3%separately.Serum urea nitrogen, creatinine, amonia, TNF and IL-6 were decreased obviously compared with control group (P<0.05) .The persistence of patients with hepatic encephalopathy disease inⅠ-Ⅱstage in thrapy group, which was higher than of patients with Ⅲ-Ⅳstage (P<0.05) .Conclusion CVVH was the modus operandi in curing the patients with gravis type hepatitis combined with hepatic encephalopathy hepatic encephalopathy patient and early treatment could develop the curative effect further.