Abstract: Objective To explore the factors influencing the prognsis of decompensation cirrhosis.Methods Clinical data of 176 decompensation cirrhosis were analyzed retrospectively, cases were divided into alive group and dead group according to their proghsis, the MELD and Child-Pugh scores, complication of the two groups were compared.Results Hepatitis B is a main cause of cirrhosis, MELD and Child-Pugh scores were higher in dead group than alive group (P<0.01) .All case had not less than one kind complication, the dead group was higher than the alive in abdominal effusion, infections, disorder of electrolyte, hepatic encephalopathy (HE) , gastrointestinal hemorrhage, and hepatorenal syndrome (HRS) incidences and complication numbers (P<0.05, P<0.01) 。Conclusion MELD scores, Child-Pugh grading and complications can influence survival rate of decompensation cirrhosis and be used as important indicators to determine prognsis of the disease.