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Characterization of hepathic pathophysiology and immunohistochemistry in patients with HBeAg positive and HBeAg negative chronic hepatitis B
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摘要: 目的探讨HBeAg阴性和阳性慢性乙型肝炎(CHB)患者组织病理学及免疫组化学的特点。方法对156例HBeAg阴性和阳性CHB患者肝组织炎症分级(G)及纤维化分期(S)的结果进行对比分析,并分别探讨两组CHB患者HBVDNA与ALT、G及S的关系,检测CHB患者肝组织HBsAg和HBcAg阳性表达率。结果HBeAg阴性CHB患者HBVDNA含量明显低于HBeAg阳性者,肝组织炎症程度高于后者,HBVDNA水平与ALT、G和S呈正相关,HBeAg阳性CHB血清HBVDNA与ALT、G无相关性。CHB患者肝组织HBcAg阳性率随炎症程度升高而升高。结论与HBeAg阳性CHB相比,HBeAg阴性者HBVDNA水平低,炎症程度高,HBVDNA水平与ALT、G、S正相关。CHB患者肝组织HBcAg阳性率随炎症程度增高而升高。Abstract: Objective To study and characterize the pathophysiology and immunohistochemistry of HBeAg positive and HBeAg negative chronic hepatitis B (CHB) .Methods A total of 156 CHB patients were divided in to two groups according to their serum HBeAg status.The grade of inflammatory activity and fibrotic stage of the liver were studied.The relationship between HBV DNA level and ALT, histological inflammatory grading, and fibrotic staging were analyzed in both groups.The expression of HBsAg and HBeAg in the liver tissue was detected by immunohistochemistry.Results The level of HBVDNA in HBeAg negative group was lower and the inflammation grading was higher than that of HBeAg positive group.HBV DNA level showed a positive correlation with ALT, inflammation grading and fibrotic staging in HBeAg negative group.No significant relation was observed between HBV DNA, inflammation grading and ALT in HBeAg positive group.The expression of HBcAg in liver tissue increased as histological inflammation grading increased.Conclusion HBeAg negative group shows lower serum HBVDNA level and advanced histologic inflammation grading than HBeAg positives.HBVDNA level has a positive correlation with ALT, inflammation grading and fibrotic staging.The expression of HBcAg in the liver tissue with CHB increases as histological inflammation grade increases.
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Key words:
- hepatitis B /
- HBeAg /
- pathohistology /
- immunochemistry
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