HBx、Twist、E-cadherin及N-cadherin在肝细胞肝癌中的表达及意义

滕菁; 唐南洪; 徐振兴; 李秀金; 金福顺; 王晓茜; 吴健朗

HBx、Twist、E-cadherin及N-cadherin在肝细胞肝癌中的表达及意义

1. 厦门市中医院检验科
2. 福建医科大学附属协和医院省肝胆外科研究所

基金项目:

厦门市科学技术局科技计划资助项目(3502Z20084021)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2009-06-20

Expression and significance of HBx, Twist, E-cadherin and N-cadherin in hepatocellular carcinoma

Research funding:

摘要

摘要: 目的探讨HBx、Twist、E-cadherin及N-cadherin在肝细胞肝癌中的表达及意义。方法采用免疫组织化学法检测72例HBsAg阳性的肝细胞肝癌组织及癌旁组织中HBx、Twist、E-cadherin及N-cadherin的表达,并与临床病理资料做对照分析。结果HCC组织中HBx、Twist、E-cadherin及N-cadherin的阳性表达率分别为84.7%、80.6%、52.8%和45.8%,而癌旁组织的阳性表达率分别为81.9%、51.4%、70.8%和27.8%。除HBx外,后三种蛋白在肝癌组织及癌旁组织的表达差异均有显著性（P<0.05）。HBx、Twist和N-cadherin的表达升高及E-cadherin表达下降分别与有无门脉癌栓和肝外是否转移相关（P<0.05）;HBx的表达分别与Twist和N-cadherin的表达呈正相关（P<0.05）;HBx、Twist和N-cadherin的表达则分别与E-cadherin的表达呈负相关（P<0.05）。结论HBx、Twist和N-cadherin的高表达以及E-cadherin的低表达...
- 肝细胞肝癌 /
- 乙肝病毒X蛋白 /
- 转录因子Twist /
- 上皮性钙粘蛋白 /
- 神经性钙粘蛋白
Abstract: Objective To investigate the expression and clinical significance of HBx, Twist, E-cadherin and N-cadherin in hepatocellular carcinoma (HCC) .Methods The expression of HBx, Twist, E-cadherin and N-cadherin in HCC and adjacent tissues were detected by immunohistochemistry technique and the relationship with clinicopathological features was analyzed.Results The positivity rate of HBx, Twist, E-cadherin and N-cadherin were 84.7%, 80.6%, 52.8% and 45.8% in HCC tissues and 81.9%, 51.4%, 70.8% and 27.8% in adjacent tissues, respectively.There was a statistically significant difference in Twist, E-cadherin and N-cadherin between the HCC and adjacent tissues (p<0.05) .The expression of HBx was positively correlated with Twist and N-cadherin in HCC and adjacent tissues, respectively.E-cadherin was negatively correlated with HBx, Twist and N-cadherin.Conclusion The higher expression of HBx, Twist, N-cadherin and E-cadherin are correlated with the invasion and metastasis of HCC.HBx might promote the change of epithelial-mesenchymal transition of HCC through Twist upregulation.
- hepatocellular carcinoma /
- HBx /
- Twist /
- E-cadherin /
- N-cadherin

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参考文献(15)

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