Survivin在胆囊腺瘤组织中的表达意义及病理诊断价值分析

张东生; 张晶晶; 王平凡; 邱娜

Survivin在胆囊腺瘤组织中的表达意义及病理诊断价值分析

兰州市第二人民医院病理科

详细信息

中图分类号: R735.8
计量
- 文章访问数: 2931
- HTML全文浏览量: 12
- PDF下载量: 850
- 被引次数: 0
出版历程
- 出版日期: 2010-01-20

The Specific Expression and Pathological Diagnostic Value of Survivin in Gallbladder Adenoma

摘要

摘要: 目的检测凋亡抑制蛋白Survivin在胆囊腺瘤的表达部位及形态特点,研究其与胆囊腺瘤发生、发展的相关性,并探讨其在胆囊腺瘤病理诊断中的应用价值。方法采用免疫组织化学技术检测25例胆囊腺瘤中Sur-vivin的表达。结果25例胆囊腺瘤中,23例Survivin蛋白胞浆阳性表达。其中21例核上表达,包括核上核样表达17例、核上泥沙样表达4例。另外胞浆弥漫表达2例。结论Survivin在胆囊腺瘤中高表达,具有向胆囊癌转化趋势,并且其特殊的表达部位及形态,在病理诊断中有着重要的应用价值。
- Survivin /
- 胆囊腺瘤 /
- 病理诊断
Abstract: Objective To evaluate the relative production and the clinical value of survivin in pathological diagnosis of gallbladder adenoma by observing the site of expression and the characteristics of survivin, the apoptosis inhibitor.Methods The expression of survivin in gallbladder adenoma was detected from 25 samples by immunohistochemical method SP.Results From a total of 25 gallbladder adenoma specimens 23 were reactive to survivin, which expressed on the cytoblast in cytoplasm with cytoblast-like 17, bedload-like 4 and diffusing 2 expression.Conclusion Survivin expression location and its characteristics may have important clinical value in pathological diagnosis of gall bladder adenoma.
- Survivin /
- Gallbladder adenoma /
- pathological diagnosis

HTML全文

参考文献(9)

[1] Hamilton SR, Aaltonen LA.世界卫生组织肿瘤分类及诊断标准系列-消化系统肿瘤病理学和遗传学[M]. (虞姬耀译) .北京:人民卫生出版社, 2006∶254.

[2]Sternberg SS.诊断外科病理学[M]. (回允中译) .第3版.北京:北京大学医学出版社, 2003∶1649.

[3]Zhu H, Chen XP, Zhang WG, et al.Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellularcarcinoma[J].World J Gastroenterol, 2005, 11 (25) ∶3855-3859.

[4]Li Fz.Survivin study:what is the next wave-[J].Cell physiol, 2003, 1997 (1) ∶8-29.

[5]Akhtar M, Gallagher L, Rohan S.Survivin:Role in diagnosis, prog-nosis, and treatment of bladder cancer[J].Adv Anat Pathol, 2006, 13 (3) ∶122-126.

[6]Zaffaroni N, Pennati M, Daidone MG.Survivin as a target for new anticancer intervention[J].J Cell Mol Med, 2005, 9 (2) ∶360-372.

[7]Cohen C, Lohmann CM, Cotsonis G, et al.Survivin expression in car-cinoma:Correlation with apoptotic marker and prognosis[J].Mod Pathol, 2003, 16 (6) ∶574-583.

[8]Kazuhiro K, Ryuichiro D, Masayuki K, et al.Survivin expression is a prognostic marker in pancreatic cancer patients[J].Surgery, 2004, 13 (2) ∶443-448.

[9]Crossman DMC, Niff JM, Li F.Expression of the apoptosis inhibitor survivin, in nonmelanoma skin cancer and gene targeting in a kerati-noyte cell line[J].Lab Invest, 1999, 79 (9) ∶121-126.

施引文献

资源附件(0)

访问统计