原发性肝癌双灌注介入治疗前后血清TNF-α和sFas水平的改变及意义探讨

陈卫; 陆忠华; 邓俊; 杨小娟; 黄利华

原发性肝癌双灌注介入治疗前后血清TNF-α和sFas水平的改变及意义探讨

无锡市传染病医院

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中图分类号: R735.7
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出版历程
- 出版日期: 2010-01-20

The change in serum TNF-α and sFas among primary liver cancer patients before and after Double intra-arterial infusion of anti-cancer agent

摘要

摘要: 目的了解原发性肝癌双灌注介入前后血清TNF-α、血清可溶性Fas（sFas）水平的变化,并探讨其临床意义。方法本研究选取75例原发性肝癌患者,其中30例行TACE治疗,45例行TACE联合脾动脉化疗药物灌注治疗,每个病例分别在术前一天、术后二周测定血清TNF-α、sFas,同时对所有病例进行近期疗效判定,另设30例正常对照组。结果肝癌患者的血清TNF-α和sFas的水平均明显高于正常对照组（P<0.01）,TACE和双灌注治疗后血清TNF-α和sFas的水平均明显低于治疗前（P<0.01）,双灌注治疗组治疗后血清TNF-α和sFas的水平分别低于TACE组治疗后水平（P<0.05）,在双灌注组中,近期疗效达有效者血清TNF-α和sFas的水平明显低于无效者（P<0.01）。结论原发性肝癌的双灌注介入治疗后血清TNF-α和sFas的水平明显降低,检测血清TNF-α和sFas的水平可以有助于预后估计。
- 原发性肝癌 /
- 肝动脉化疗栓塞 /
- 双灌注介入 /
- TNF-α /
- sFas
Abstract: Objective To study the clinical significance of change in serum TNF-αand sFas among primary liver cancer patients before and after Double intra-arterial infusion of anti-cancer agent.Methods A total of 75 patients with primary liver cancer were treated with TACE (35 patients) , and TACE Combined with Splenic Arterial Set-catheter Infusion (45 patients) .In addition, 30 patients were included in the study as a normal control group.The patients serum TNFαand sFas were determined before and two weeks after therapy and all the patients were evaluated for the effect of treatment simultaneously.Results Serum TNF-α and sFas levels of primary liver cancer patients were higher than the normal control group (P < 0.01) .Serum TNF-α and sFas levels in patients treated with TACE and Double intra-arterial infusion of anti-cancer agents were lower than the control group (P < 0.01) .The serum TNF-α and sFas levels of patients treated with Double intra-arterial infusion anti-cancer agent were lower than the TACE treatment group (P < 0.05) .Double intra-arterial infusion anti-cancer agent therapy had shown a significant effect on serum TNF-α and sFas's levels of the treated patients than the patients that were not treated (P < 0.01) .Conclusion Patients that were treated with Double intraarterial infusion of anti-cancer agent were shown a significant decrease in serum TNF-α and sFas measurement.Therefore, these parameters can be used to estimate disease prognosis.
- primary liver cancer /
- double intra-arterial infusion of anti-cancer agent /
- tumor necrosis factor α /
- serum soluble Fas /

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