腺苷蛋氨酸治疗药物性淤胆型肝炎疗效观察

周淑云; 崔英

腺苷蛋氨酸治疗药物性淤胆型肝炎疗效观察

周淑云,
崔英

1. 中国石油天然气集团公司中心医院感染科
2. 长春市南关区医院

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中图分类号: R575.1
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出版历程
- 出版日期: 2010-01-20

The effect of ademetionine on patients with drug-induced cholestatic hepatitis

摘要

摘要: 目的探讨腺苷蛋氨酸对药物性淤胆型肝炎的疗效。方法将88例药物性淤疸型肝炎随机分为治疗组46和对照组42例,治疗组在一般保肝治疗基础上加用腺苷蛋氨酸1000毫克溶于5%葡萄糖液250毫升每日1次静点,对照组仅给予一般保肝治疗,疗程均4周。结果治疗2周时,治疗组有效率明显高于对照组,两组间的差异有统计学意义(P<0.05)。治疗4周时,治疗组与对照组的有效率差异无统计学意义(P>0.05),但两组的临床治愈率的差异有统计学意义(P<0.05)。结论腺苷蛋氨酸在治疗药物性淤胆型肝炎上有较好疗效,能较早促进损伤的肝细胞修复、再生以缓解症状、体征及肝功恢复,是目前较理想的治疗药物性淤胆型肝炎的药物。
- 腺苷蛋氨酸 /
- 淤胆型 /
- 药物性肝炎
Abstract: Objective To investigate the effect of ademetionine on patients with cholestatic hepatitis induced by drugs.Methods 88 patients with drug induced cholestatic hepatitis were randomly divided into control group (n =42) and treatment group (n=46) .The liver protectant therapy combined with ademetionine 1000 mg in 5% glucose solution of 250 ml were given intravenously per day in treatment group for 4 weeks.The control group received liver protectant therapy only.Results The combined treatment was more effective in the treatment group than the control group after 2 weeks of treatment (P < 0.05) .At the 4th week of treatment there was no significance difference between the two groups (P > 0.05) .However, the recovery rate difference was statistically significant between the two groups (P < 0.05) .Conclusion Ademetionine is effective and safe, in the treatment of patients with drug-induced cholestatic hepatitis, in promoting the liver metabolism and repairing the hepatic cell.
- Ademetionine /
- Cholestatic /
- Hepatitis induced by drugs

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参考文献(8)

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