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视黄醇结合蛋白4和细胞角蛋白18两个新发现的非酒精性脂肪肝相关指标

张莉 施军平

引用本文:
Citation:

视黄醇结合蛋白4和细胞角蛋白18两个新发现的非酒精性脂肪肝相关指标

基金项目: 

浙江省重大科技专项重点社会发展项目(编号2008C13027-1); 

详细信息
  • 中图分类号: R575.5

Retinol-binding protein 4 and cytokeratin 18 are two newly discovered markers associated with nonalcoholic fatty liver disease


Research funding: 

 

  • [1]Berggard I.Studies on the plasma protein in normal human urine[J].Clinica Chimica Acta, 1961, 6 (3) :413-429.
    [2]陈健, 周度金.视黄醇类结合蛋白的分类、结构及功能[J].生命的化学, 2004, 24 (2) :112-115.
    [3]Rocchi M, Covone A, Romeo G, et al.Regional mapping of RBP4to10q23-q24and RBP1to3q21-q22in man[J].Somat Cell Mol, 1989, 15 (2) :185-190.
    [4]Flower DR, North AC, SansomCE.The lipoealin protein family:struc-turaland sequence overview[J].Biochim Biophys Aeta, 2000, 1482 (1-2) :9-24.
    [5]Stefano J, Keith G, Graham J, et al.Charaterization of two post trans-lationally processed forms of human serum retinol-bindind protein:altered ratios in chronic renalfailure[J].J Lipid Research, 1995, 36 (5) :1817-1818.
    [6]Guo XH, Chu MX, Zhou ZX.Molecular biology of the retinol-bind-ing proteins and their genes[J].Yi Chuan, 2004, 26 (2) :257-262.
    [7]Yang Q, Graham TE, Mody N, et al.Serum retinol bindingprotein4cont ributes to insulin resistance in obesity and type2diabetes[J].Nature, 2005, 436 (7049) :356-362.
    [8]Seo J A, Kim NH, Park S Y, et al.Serum retinol-binding protein4levels are elevated in non-alcoholic fatty liver disease[J].Clini-cal Endocrinology, 2008, 68 (4) :555-560.
    [9]Huang J F, Dai C Y, Yu ML, et al.Serumretinol-binding protein4is inversely correlated with disease severity of chronic hepatitis C[J].J Hepatology, 2009, 50 (3) :471-478.
    [10]Seo JA, Kim NH, Park SY, et al.Serum retinol-binding protein4levels are elevated inon2alcoholicfattyliverdisease[J].Clinical Endo-crinology, 2008, 68 (4) :55-560.
    [11]Graham TE, Yang Q, Bluher M, et al.Retinol-binding protein4and insulin resistance in lean, obese, and diabetic subject[J].NEn-gl J Med, 2006, 354 (24) :2552-2563.
    [12]Wu H, Jia W, Bao Y, et al.Serum retinol binding protein4and nonalcoholic fat ty liver disease in patient s wit h type2diabetesmell-itus[J].Diabetes Res Clin Pract, 2008, 79 (2) :185-190.
    [13]Yan K K, Palmer C S, Lloyd A R, et al.Relationship of Retinol Binding Protein-4with Liver Injury in Morbidly Obese Subjects[J].Hepatology, 2009, 50 (4) :S789A.
    [14]Barak V, Goike H, Panaretakis KW, et al.Clinical Utility of cytok-eratins as tumor markers[J].ClinBiochera, 2004, 37 (7) :1529-1540.
    [15]Linder S, Havelka AM, Ueno T, et a1.Determiningtumor apoptosis and necrosis in patient serumusingcytokeratin18as a biomarker[J].Cancer Lett, 2004, 24 (1) :1-9.
    [16]Petta S, Camma C, Marco V D, et al.High Level RBP4Expres-sion is Associated with the Severity of Fibrosis in NAFLD Patients[J].Hepatology, 2009, 50 (4) :S800A.
    [17]Yagmur E, Weiskirchen R, Gressner AM, et al.Insulin Resistance in Liver Cirrhosis Is Not Associated With Circulating Retinol-Bind-ing Protein4[J].Diabetes Care, 2007, 30 (5) :1168-1172.
    [18]Tacke F, Weiskirchen R, Trautwein C, et al.Liver Function Criti-cally Determines Serum Retinol-Binding Protein4 (RBP4) Levels in Patients with Chronic Liver Disease and Cirrhosis[J].Hepotolo-gy.2008, 48 (1) :28-37.
    [19]Zatioukal K, Stumptner C, Fuchsbichler A, et al.The keratin cy-toskeleton in liver diseases[J].Pathol, 2004, 4 (4) :367-376.
    [20]Gilbert S, Lorange A, Daigle N, et al.Simple epithelium keratins8and18provide resistance to Fas-mediated apoptosis.The protection occurs through a receptor-targeting modulation[J].J CellBiol, 2001, 154 (4) :763-773.
    [21]李娟, 石英, 武聚山, 等.角蛋白K18及其33、52位丝氨酸磷酸化在HBV感染肝脏疾病中的表达及意义[J].临床肝胆病杂志, 2008, 24 (4) :213-214.
    [22]Gonzalez-Quintela A, Garcia J, Campos J.Serum cytokeratins in alcoholic liver disease:contrasting levels of cytokeratin-18and cy-tokeratin-19[J].Alcohol, 2006, 38 (1) :45-49.
    [23]Prati D, Taioli E, Zanella A, et al.Updated definitions of healthy ranges for serum alanine aminotransferase levels[J].Annal Intern Med, 2002, 137 (1) :1-10.
    [24]Malik R, Chang M, Bhaskar K, et al.The clinical utility of biomark-ers and the nonalcoholic steatohepatitis CRNliver biopsy scoring sys-tem in patients with nonalcoholic fatty liver disease[J].J Gastroen-terol Hepatol, 2009, 24 (4) :564-568.
    [25]Diab DL, Yerian L, Schauer P, et al.Cytokeratin18Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients[J].Clinical Gastroenterology and Hep-atology, 2008, 6 (11) :1249-1254.
    [26]Diab D, Yerian L, Schauer P, et al.Cytokeratin18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease[J].J Pediatr Gastroenterol Nutr, 2008, 47 (4) :481-485.
    [27]Gonzalez-Quintela A, Mallo N, Mella C, et al.Serum levels of cy-tokeratin-18 (tissuepolypeptide-specific antigen) in liver diseases[J].Liver International, 2006, 26 (10) :1217-1224.
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  • 出版日期:  2010-02-20
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