原发性肝癌患者血清VEGF、TGF-β1表达水平与浸润转移关系的研究

孙屹峰; 张超贤; 秦咏梅

原发性肝癌患者血清VEGF、TGF-β1表达水平与浸润转移关系的研究

新乡医学院第一附属医院

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中图分类号: R735.7
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出版历程
- 出版日期: 2010-02-20

The Serum Levels of VEGF and TGF-β1 in Patients with Primary Hepatic Carcinoma

摘要

摘要: 目的探讨原发性肝癌患者血清血管内皮生长因子（VEGF）及转化生长因子-β1（TGF-β1）的表达水平与肝癌浸润和转移的相关性。方法采集98例原发性肝癌患者和4O例健康志愿者的血清。应用ELISA法检测受检者血清VEGF、TGF-β1的表达水平,并分析其与临床病理因素之间的关系。结果原发性肝癌患者血清VEGF与TGF-β1水平显著高于正常对照组（P<0.01）,患者血清VEGF、TGF-β1的表达水平与患者与肿瘤的组织学分级、浸润深度、转移密切相关（P<0.01）。血清VEGF与TGF-β1水平呈显著正相关（r=0.418,P<0.01）。结论VEGF和TGF-β1与原发性肝癌的病情发展、浸润和转移有密切相关性,临床上,血清VEGF、TGF-β1的表达水平可作为了解原发性肝癌生物学行为和判断预后的指标。
- 血管内皮生长因子 /
- 转化生长因子-β1 /
- 原发性肝癌 /
- 血清 /
- 浸润 /
- 转移
Abstract: Objective To evaluate the relationship between serum levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) with the development, invasion and metastasis of primary hepatic carcinoma (PHC) .Methods Serum samples were collected from 98 patients with PHC and 40 healthy controls.The expression of serum VEGF and TGF-β1 were measured by ELISA and their relationship to clinical parameters were analyzed.Results The serum levels of VEGF and TGF-β1 were significantly increased and correlated with tumor differentiation, invasion and metastasis in PHC patients compared to the healthy controls (P<0.05) .VEGF was positively correlated with TGF-β1.Conclusion Serum levels of VEGF and TGF-β1 are closely correlated with invasion and metastasis of PHC.Therefore, their expression in serum might be a useful tool for the evaluation of the biological behavior and prognosis of PHC.
- vascular endothelial growth factor /
- transforming growth factor-β1 /
- primary hepatic carcinoma /
- serum /
- invasion /
- metastasis

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参考文献(12)

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