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The relationship between HBV DNA loads and MELD scores during the process from acute attack to remission of liver disease in HBeAg negative chronic hepatitis B
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摘要: 目的弄清HBeAg阴性慢性乙型肝炎不同程度肝病急性发作的极期及缓解期HBV DNA载量的变化及其差别。方法观察并比较62例乙型肝炎慢加急性肝衰竭和48例慢性乙型肝炎重度肝病急性发作极期和缓解期的MELD评分和HBV DNA载量。结果乙型肝炎慢加急性肝衰竭组和慢性乙型肝炎重度组极期和缓解期的MELD评分及HBV DNA载量均存在差别。乙型肝炎慢加急性肝衰竭组缓解期HBV DNA载量水平低于慢性乙型肝炎重度组。结论无论乙型肝炎慢加急性肝衰竭还是慢性乙型肝炎重度,随着肝病急性发作极期至缓解期MELD评分的减少,HBV DNA载量发生自发性下降,而且,慢加急性肝衰竭下降水平大于慢性乙型肝炎重度。Abstract: Objective To fully understand the changes and differences of HBV DNA loads during fastigium and remission in different degrees of acute attack of liver disease in HBeAg negative chronic hepatitis B.Methods To observe and compare the model for end-stage liver disease (MELD) scores and HBV DNA loads during fastigium and remission in an acute attack of liver disease in 62 cases with acute-on-chronic liver failure and 48 cases with severe chronic hepatitis B.Results There were differences in MELD scores and HBV DNA loads during fastigium and remission in acute-on-chronic liver failure group and severe chronic hepatitis B group, and the HBV DNA loads during remission was lower in acute-on chronic liver failure than in severe chronic hepatitis B.Conclusion Regardless of acute-on-chronic liver failure or severe chronic hepatitis B, HBV DNA loads occurred to decrease spontaneously along with the decline of MELD scores from the fastigium to remission in acute attack of liver failure, and the decreased levels of HBV DNA loads were more obviously in acute-on-chronic liver failure group than severe chronic hepatitis B group.
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Key words:
- hepatitis B /
- chronic /
- hepatitis B virus /
- DNA
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