Clinical analysis of 11 cases of hepatic veno-occlusive disease caused by Chinese herbal medicine
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摘要: 目的评估各种常规临床检测方法对中草药所致肝小静脉闭塞病(HVOD)的诊断价值,并探寻评价疾病转归及预后的方法。方法采用回顾性研究方法,分析我院近3年间服用中草药所致11例HVOD的临床表现、生化指标和影像学特点。结果所有患者均有明确用药史,7例患者服用土三七,2例患者服用雷公藤,2例患者服用不明中草药,CT对HVOD的诊断有重要意义,死亡4例患者均为重型患者。结论我国肝小静脉闭塞病的诊断应重视患者用药史,HVOD患者的疾病分型对病情评估有重要意义。Abstract: Objective TO assess a variety of routine detection methods for the value of clinical diagnosis of Hepatic veno-occlusive disease (HVOD) caused by Chinese herbal medicine and explore the evaluation method of disease outcome and prognosis.Methods According to retrospective study.we analyze the clinical manifestations, biochemical and imaging features of 11 cases with HVOD in our hospital in the last three years.Results All patients have a clear medical history, 7 cases taking the Gynura Rhizome, 2 cases taking the Common Threewingnut Root, 2 cases taking unknown Chinese herbal medicine.CT plays an important role in the diagnosis of HVOD, all 4 deaths are severe patients.Conclusion The diagnosis of HVOD should pay attention to the medication history of patients, The classification of HVOD patients is important to assess the disease.
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Key words:
- hepatic veno-occlusive disease /
- drugs
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[1]Chen Z, Huo JR.Hepatic veno-occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations[J].Neth J Med, 2010, 68 (6) :252-260. [2]Cefalo MG, Maurizi P, Arlotta A, et al.Hepatic veno-occlusive disease:a chemotherapy-related toxicity in children with malignancies[J].Paediatr Drugs, 2010, 12 (5) :277-284. [3]吴国琳, 余国友, 陈玖.中药土三七致肝小静脉闭塞病临床分析[J].中国中药杂志, 2008, 33 (20) :2402-2404. [4]DeLeve LD, Shulman HM, McDonald GB.Toxic injury to hepatic sinusoids:sinusoidal obstruction syndrome veno-occlusive disease[J].Semin Liver Dis, 2002, 22 (1) :27-42. [5]Mc Donald GB, Hinds MS, Fisher ID, et al.Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation a cohort study of 355 patients[J].Ann Intern Med, 1993, 118 (4) :255-267. [6]陈毅鹏, 李君, 柴菊爱, 等.肝静脉闭塞病的临床和病理研究[J].中华消化杂志, 2006, 26 (4) :224-226. [7]Jones RJ, Lee KSK, Beschomer WE, et al.Veno-occlusive disease of the liver following bone marrow transplantation[J].Transplantation, 1987, 44 (6) :778-783. [8]Mc Donald GB, Sharma P, Matthews DE, et al.Veno-occlusive disease of the liver after bone marrow transplantation:diagnosis, incidence and predisposing factors[J].Hepatology, 1984, 4:116-122. [9]Matsumoto Y, Horiike S, Sakagami J, et al.Early ultrasonographic diagnosis and clinical follow-up of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in a patient with acute lymphoblastic leukemia[J].Intern Med, 2009, 48 (10) :831-835. [10]Pei YG, Hu DY, Shen YQ, et al.The value of MSCT and MRI in the diagnosis of hepatic veno-occlusive disease[J].Zhonghua Gan Zang Bing Za Zhi, 2010, 18 (2) :150-152. [11]Richardson PG, Soiffer RJ, Antin JH.et al.Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation:a multicenter, randomized, dose-finding trial[J].Biol Blood Marrow Transplant, 2010, 16 (7) :1005-1017.
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