门冬氨酸鸟氨酸在胃肠道肿瘤伴乙型肝炎病毒感染患者化疗中的保护作用

张志红; 倪秉强; 陈日新

门冬氨酸鸟氨酸在胃肠道肿瘤伴乙型肝炎病毒感染患者化疗中的保护作用

广西医科大学第五临床医学院柳州市人民医院

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中图分类号: R512.62
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出版历程
- 出版日期: 2011-02-20

Protective effect of Ornithine Aspartate on chemotherapy of gastrointestinal tumors with HBV infection

摘要

摘要: 目的观察门冬氨酸鸟氨酸在乙型肝炎病毒(HBV)感染的胃肠道恶性肿瘤化疗中的保护作用。方法 98例胃肠道恶性肿瘤随机分为治疗组和对照组,治疗组47例在FOLFOX方案化疗前3 d及疗程中每日静脉滴注10 g门冬氨酸鸟氨酸,对照组51例单用FOLFOX方案化疗,两组均在治疗前后PCR检测HBV DNA载量,化疗前及化疗期间检测肝功能、血常规、T淋巴细胞亚群,观察体重及KPS评分变化。结果治疗后对照组总胆红素、ALT、AST在II度以上升高发生率高于治疗组,体重下降及KPS评分下降发生率高于治疗组;II度以上骨髓抑制发生率两组差异无统计学意义;两组T淋巴细胞亚群检测差异无统计学意义;两组患者治疗后血清HBV DNA拷贝数均高于治疗前,但两组间比较差异无统计学意义。结论门冬氨酸鸟氨酸能减轻伴HBV感染的胃肠道恶性肿瘤化疗后肝功能损伤,改善病人体力、体重等一般状况,提高患者对化疗的耐受性。
- 胃肠肿瘤 /
- 肝炎,乙型 /
- 天冬氨酸 /
- 鸟氨酸
Abstract: Objective To study the protective effect of Ornithine Aspartate on chemotherapy of gastrointestinal tumors with HBV Infection.Methods 98 cases of gastrointestinal tumors with HBV were divided randomly into two groups, 47 cases in observation group were treated with Ornithine Aspartate (10 g per day venous instillation) 3 days before and during the FOLFOX chemotherapy, and 51 cases in control group were treated with FOLFOX chemotherapy alone.HBV DNA load was detected with PCR before and during chemotherapy.Liver function, blood routine, weight, T lymphocyte subsets and KPS score were also detected before and during chemotherapy.Results The increment in total bilirubin, ALT and AST greater than 2 times in control group was higher than that in observation group after treatment, and weight loss and decline in KPS score in control group was higher than that in observation group;Bone marrow suppression and T lymphocyte subsets showed no significant difference between the two groups.The number of HBV DNA copy was increased after treatment in both the groups, but there was no significant difference between the two groups.Conclusion Ornithine Aspartate was effective in the prevention and treatment of the liver function damage caused by chemotheraphy in patients with gastrointestinal tumors with HBV.It also improved weight loss and physical activity and enhanced the tolerance to therapy in patients with FOLFOX chemotherapy.
- gastrointestinal neoplasms /
- hepatitis B /
- aspartic acid /
- ornithine

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参考文献(12)

[1]Hui CK, Cheung WW, Leung KW, et al.Retracted:outcome and immune reconstitution of HBV-specificimmunity in patients with reactivation of occult HBVinfection after alemtuzumab-containing chemotherapyregimen[J].Hepatology, 2008, 48 (2) :1-10.

[2]Hoofnagle JH.Reactivation of hepatitis B[J].Hepatology, 2009, 49 (5 Suppl) :S156-165.

[3]Faggioli P, DePaschale M, Tocci A, et al.Acutehepatictoxicity during cyclic chemotherapy in non-Hodgkinslymphoma[J].Haematologica, 1997, 82 (1) :38-42.

[4]Farrow AC, Buchanan GR, Zwiener RJ, et al.Serumaminotransferase elevation during and followingtreatment of childhood acute lymphoblasficleukemia[J].JClin Oncol, 1997, 15 (4) :1560-1566.

[5]Steinberg JL.Hepatitis B virus reactivation inpatients undergoing cytotoxic chemotherapy for solidtumours:precore/eoremutations may play an importantrole[J].J Med Virol, 2000, 60 (3) :249-255.

[6]陈孝治.瑞甘[J].中南药学, 2004, 2 (4) :254-255.

[7]金晶, 曾凡波, 周燕, 等.门鸟氨酸对肝脏的保护作用[J].医药导报, 2003, 22 (11) :241-242.

[8]王传中.门冬氨酸鸟氨酸对急性中毒性肝损伤的保护作用[J].中原医刊, 2008, 35 (2) :25-27.

[9]郁国强, 李红军, 宣江华, 等.门冬氨酸鸟氨酸 (瑞甘) 治疗慢性乙型肝炎36例[J].世界感染杂志, 2006, 6 (5) :455-456.

[10]傅志超, 程惠华, 李东石, 等.门冬氨酸鸟氨酸在原发性肝癌放疗时放射性肝损伤的保护作用[J].临床军医杂志, 2009, 37 (2) :220-222.

[11]刘谢添.天门冬氨酸鸟氨酸对肿瘤化疗后肝功能损害的保护作用[J].检验医学与临床, 2009, 6 (9) :718-719.

[12]史建军, 邵汛帆, 陈冬平, 等.门冬氨酸鸟氨酸在恶性淋巴瘤伴乙肝病毒感染放化疗中的保护作用[J].肿瘤防治研究, 2006, 33 (1) :57-58.

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