肝纤维化无创诊断的研究进展

曹玉宁; 李森林

肝纤维化无创诊断的研究进展

聊城市人民医院消化内科

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2011-02-20

Research in the progress of non-invasive diagnosis of liver fibrosis

摘要

摘要: 肝纤维化是一种由不同肝病发展而来的威胁生命的疾病,是最常见的死因之一,以细胞外基质增加,组织重列并改建为特点。判断肝纤维化程度及炎症活动度的最可靠指标为肝脏活检,但活检是一项有创检查,应用有一定的限制,因而寻找准确、可靠地无创检查方法为肝纤维化的病情判断和疗效考核提供依据是非常有必要的。近年来,随着血清学和影像学的发展,血清标志物模型、瞬态弹性成像等可以比较准确的诊断肝纤维化,减少了对肝活检的需要,但是由于其各自的缺点至今没有一种无创方法可以替代肝活检的金标准地位,寻找一种理想的标志物仍需继续努力。
- 肝硬化
Abstract: Liver fibrosis is a life-threatening disease evolving from different liver disease,is one of the most common cause of death.Fibrosis is characterized by excessive deposition of extracellular matrix in the tissue and tissue restatement as consequence of chronic liver damage.Liver biopsy is the most reliable indicator of the degree of hepatic fibrosis and inflammatory activity,but biopsy is an invasive examination.There are some risks and limitations,so it is necessary to look for an accurate and reliable non-invasive method to provide the basis for diagnosis and treatment of liver fibrosis.In recent years,advances in serology and imageology such as serum marker panels,FibroScan,et al can assess fibrosis accurately and reduce the need for a liver biopsy.But at present,all have failed to completely replace liver biopsy because of their respective limitations in current researches.The searching for an ideal surrogate is still in progress.
- liver cirrhosis

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参考文献(31)

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