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药物性肝损伤的防范与思考

白文元 刘娜

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药物性肝损伤的防范与思考

详细信息
  • 中图分类号: R595.3

Prevention and thorough consideration of drug induced liver injury

  • 摘要: 近年来,药物性肝损伤(DILI)在我国发病率呈明显的增高趋势,急性重症药物性肝损伤致死率也在增加,严重影响了人民的健康。主要影响因素包括:抗生素的滥用、药品广告不切实际的宣传、农村地区过期药品的使用以及不当的用药方法等等,以上均导致了药物性肝损伤的发生。这就促使我们必须对药物性肝损伤引起足够的重视,为此,必须制定切实可行的防范措施,尽可能避免DILI的发生。

     

  • [1]Bernal W,Auzinger G,Dhawan A,et al.Acute liver failure[J].Lancet,2010,376(9736):190-201.
    [2]Russmann S,Jetter A,Kullak-Ublick GA.Pharma-cogene-tics of drug-induced liver injury[J].Hepatology,2010,52(2):748-761.
    [3]尚佳,徐芸,杨玉秀,等.人工肝支持系统治疗药物性肝损伤32例[J].中华肝脏病杂志,2005,13(11):836-838.
    [4]王艳,赵龙凤,王勤英.药物性肝损伤66例分析[J].中华肝脏病杂志,2010,18(9):715-716.
    [5]Hunt CM.Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury:A systematic review[J].Hepatology,2010,52(6):2216-2222.
    [6]Reuben A,Koch DG,Lee WM.Drug-induced acute liver failure:Results of a U.S.multicenter,prospective study[J].Hepatology,2010,52(6):2065-2076.
    [7]Ekins S,Williams AJ,Xu JJ.A predictive ligand-based bayesian model for human drug-induced liver injury[J].Drug Metab Dispos,2010,38(12):2302-2308.
    [8]Vuppalanchi R,Hayashi PH,Chalasani N,et al.Dul-oxetine hepatotoxicity:a case-series from the drug-induced liver injury network[J].Aliment Pharmacol Ther,2010,32(9):1174-1183.
    [9]Karatopuk DU,G?k?1men A.Effect of tenoxicam on rat liver tissue[J].Turk J Gastroenterol.2010,21(2):146-152.
    [10]Kelava T,Cavar I,Culo F.Influence of small doses of various drug vehicles on acetaminophen-induced liver injury[J].Can J Physiol Pharmacol,2010,88(10):960-967.
    [11]Schumaker AL,Okulicz JF.Meropenem-induced vanishing bile duct syndrome[J].Pharmacotherapy,2010,30(9):953.
    [12]Nú?ez M.Clinical syndromes and consequences of antiretroviral-related hepatotoxicity[J].Hepatology,2010,52(3):1143-1155.
    [13]Tai WP,Yue H,Zhai HZ.Zhixue capsule caused seven cases of drug induced hepatitis[J].Hepatogastroenterology,2010,57(99-100):571-572.
    [14]Devarbhavi H,Dierkhising R,Kremers WK.Antitu-berculosis therapy drug-induced liver injury and acute liver failure[J].Hepatology,2010,52(2):798-799.
    [15]Park WB,Kim W,Lee KL,et al.Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis[J].J Infect,2010,61(4):323-329.
    [16]Hou FQ,Wang TL,Liu X,et al.The clinical and histological characteristics and outcomes of drug induced chronic liver injury after removing causative drugs[J].Hepatogastroenterology,2010,57(99-100):554-561.
    [17]Fontana RJ.Approaches to the study of drug-induced liver injury[J].Clin Pharmacol Ther,2010,88(3):416-419.
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  • 出版日期:  2011-03-20
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