肝硬化时器官血液循环的病理生理改变

董刚; 凌宾芳; 任波

肝硬化时器官血液循环的病理生理改变

解放军302医院麻醉科

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中图分类号: R575.2
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出版历程
- 出版日期: 2011-03-20

Pathophysiology of organ circulation in cirrhosis

摘要

摘要: 肝硬化患者常常表现为全身血管阻力下降和心输出量增加的高动力循环状态,但是由于机体不同部位扩血管和缩血管作用的不平衡,各组织器官的血管床处于不同的灌注水平和异常的循环状态,此改变在疾病的发生发展过程中起重要作用。本文就肝硬化时各器官血液循环的病理生理改变作一综述。
- 肝硬化 /
- 血液循环
Abstract: Although the hyperdynamic syndrome in cirrhosis reflects increased cardiac output and reduced systemic vascular resistance,it covers the imbalance between vasodilating and vasoconstricting forces which contributes to an abnormal distribution and infusion of blood volume in the vascular areas of organs.With the progression of the liver disease the abnormal circulation bears a significant relationship with the severity of the cirrhosis.This review summarizes the pathophysiology of organ circulation.
- cirrhosis /
- organ circulation

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参考文献(20)

[1]Mller S,Henriksen JH.Cardiovascular complications ofcirrhosis[J].Postgrad Med J,2009,85(999):44-54.

[2]叶乐驰,张启瑜.门静脉高压症内脏血管扩张机制的研究进展[J].国际外科学杂志,2006,33(1):7-11.

[3]Henriksen JH,M?ller S.Cardiac and systemic hae-modynamic complications of liver cirrhosis[J].ScandCardiovasc J,2009,43(4):218-225.

[4]Large DA,Shah VH.Nitric oxide and portal hypertension:interface of vasoreactivity and angiogenesis[J].J Hepatol,2006,44(1):209-216.

[5]Rockey DC.Hepatic blood flow regulation by stellatecells in normal and injured liver[J].Semin Liver Dis,2001,21(3):337-349.

[6]Wiest R,Groszmann RJ.The paradox of nitric oxide incirrhosis and portal hypertension:too much,not enough[J].Hepatology,2002,35(2):478-491.

[7]M?ller S,Bendtsen F,Christensen E,et al.Prognosticvariables in patients with cirrhosis and oesophageal variceswithout prior bleeding[J].J Hepatol,1994,21(6):940-946.

[8]Rodríguez-Roisin R,Krowka MJ,HervéP,et al.Pul-monary-Hepatic vascular Disorders(PHD)[J].Eur Respir J,2004,24(5):861-880.

[9]Rodriguez-Roisin R,Krowka MJ.Hepatopulmonarysyndrome-a liver-induced lung vascular disorder[J].N EnglJ Med,2008,358(22):2378-2387.

[10]Philippe H,Jerome LP,Benjamin S,et al.Pulmonaryvascular abnormalities in cirrhosis[J].Best Pratt Res ClinGastroenterol,2007,21(1):141-159.

[11]Vincent Ho.Current concepts in the management ofhepatopulmonary syndrome[J].Vasc Health Risk Manag,2008,4(5):1035-1041.

[12]Turban S,Thuluvath PJ,Atta MG.Hepatorenal syndrome[J].World J Gastroenterol,2007,13(30):4046-4055.

[13]Arroyo V,Terra C,Ginès P.Advances in the pathogenesisand treatment of type-1 and type-2 hepatorenalsyndrome[J].J Hepatol,2007,46(5):935-946.

[14]Blei AT.Monitoring cerebral blood flow:a useful clinical tool in acute liver failure?[J].Liver Transpl,2005,11(11):1320-1322.

[15]Iwakiri Y,Groszmann RJ.The hyperdynamic circulation ofchronic liver diseases:from the patient to the molecule[J].Hepatology,2006,43(2 Suppl 1):S121-131.

[16]Iversen P,S?rensen M,Bak LK,et al.Low cerebral ox-ygen consumption and blood flow in patients with cirrhosisand an acute episode of hepatic encephalopathy[J].Gastroenterology,2009,136(3):863-871.

[17]Gines P,Arroyo V,Rodes J,et al.Ascites and renaldysfunction in liver disease:Pathogenesis,Diagnosis,andTreatment[M].Malden:Blackwell,2005:139-155.

[18]Carrella M,Hunter JO,Fazio S,et al.Capillary blood flowto the skin of forearm in cirrhosis[J].Angiology,1992,43(12):969-974.

[19]Maroto A,Ginès P,Arroyo V,et al.Brachial and femoralartery blood flow in cirrhosis:relationship to kidneydysfunction[J].Hepatology,1993,17(5):788-793.

[20]Luca A,Garcia-Pagan JC,Feu F,et al.Noninvasivemeasurement of femoral blood flow and portal pressureresponse to propranolol in patients with cirrhosis[J].Hepatology,1995,21(1):83-88.

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