女性非酒精性脂肪性肝病脂联素水平与胰岛β细胞功能及胰岛素抵抗的相关性

查英; 刘军; 盛励; 陈灶萍; 杨玲娣; 陈钦达; 廖晓寰; 孟令平

女性非酒精性脂肪性肝病脂联素水平与胰岛β细胞功能及胰岛素抵抗的相关性

1. 复旦大学附属上海市第五人民医院内分泌科
2. 复旦大学附属上海市第五人民医院生化室
3. 复旦大学附属上海市第五人民医院免疫室
4. 复旦大学附属上海市第五人民医院核磁共振室

基金项目:

上海市卫生局青年科研基金资助项目(054Y44)；

详细信息

中图分类号: R575.5
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出版历程
- 出版日期: 2011-04-20

Relationship between adiponectin and β-cell function and insulin resistance in female patients with nonalcoholic fatty liver disease

Research funding:

摘要

摘要: 目的探讨女性非酒精性脂肪性肝病(NAFLD)脂联素水平与胰岛β细胞功能、胰岛素抵抗之间的关系。方法应用高葡萄糖钳夹技术检测了9例NAFLD组和7例正常对照组(C)胰岛β细胞功能和胰岛素敏感性,采用梯度回波化学位移MRI评估了肝脏inphase(IP)值和outphase(OP)值,并测定了皮下脂肪面积(SA)、内脏脂肪面积(VA)。用酶联免疫法测定脂联素(adiponectin)水平。结果 NAFLD组空腹胰岛素(FINS)、胰岛素分泌第一时相(1Ph)、葡萄糖代谢清除率(M)、胰岛素敏感指数(ISI)和脂联素水平低于C组(P<0.05)。Spearman相关分析显示,脂联素与M(r=0.526,P=0.036)、ISI(r=0.682,P=0.005)、1Ph(r=0.676,P=0.003)、肝脏OP值(r=0.682,P=0.004)和肝脏OP/IP(r=0.594,P=0.015)呈正相关。结论女性NAFLD患者脂联素水平降低,低脂联素血症可能与胰岛素抵抗、胰岛功能早期损害密切相关。
- 脂肪肝 /
- 脂联素 /
- 胰岛 /
- 胰岛素抗药性
Abstract: Objective To investigate adiponectin level in female patients with nonalcoholic fatty liver disease (NAFLD) , and to explore the relationship between adiponectin and ?-cell function and insulin resistance.Methods The investigation used case control study.Nine patients with nonalcoholic fatty liver disease (NAFLD) and seven control subjects (C) were analyzed for ?-cell function and insulin resistance by hyperglycemic clamp.Serum adiponectin was assayed by ELISA.Subcutaneous adipose areas (SA) , visceral adipose areas (VA) , liver inphase (IP) and outphase (OP) were measured by MRI.Results The result showed the levels of fasting insulin (FINS) , first phase insulin release (1Ph) , glucose disposal rates (M) , insulin sensitivity index (ISI) , and adiponectin were significantly lower in NAFLD than those in C group (P<0.05) .Spearman correlation analysis showed adiponectin was positively associated with M (r=0.526, P=0.036) , ISI (r=0.682, P=0.005) , 1Ph (r=0.676, P=0.003) , liver OP (r=0.682, P=0.004) and OP/IP (r=0.594, P=0.015) .Conclusion The result suggested that adiponectin level was decreased in female patients with NAFLD.Hypoadiponectinemia may be associated with insulin resistance and early beta-cell dysfunction in NAFLD.
- fatty liver /
- adiponectin /
- islets of langerhasn /
- insulin resistance

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参考文献(10)

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