抑癌基因APC、RASSF1A、WIF-1启动子区域甲基化与消化系肿瘤

张慧景; 李胜棉

抑癌基因APC、RASSF1A、WIF-1启动子区域甲基化与消化系肿瘤

河北医科大学第四医院消化内科

基金项目:

河北省科技计划项目(09276101D-9)；

详细信息

中图分类号: R735
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出版历程
- 出版日期: 2011-04-20

Promoter methylation in APC, RASSF1A, WIF-1 gene in digestive system tumors

Research funding:

摘要

摘要: 消化系统肿瘤是常见的人类恶性肿瘤,目前研究认为抑癌基因启动子区域的异常甲基化与肿瘤的形成有关。在此综述APC、RASSF1A、WIF-13种抑癌基因启动子区域的异常甲基化与消化系统肿瘤的关系。
- 消化系统肿瘤 /
- 基因,肿瘤抑制 /
- 原癌基因 /
- DNA甲基化 /
- 启动区(遗传学) /
- 基因,APC /
- 基因,Ras
Abstract: The digestive system tumor is very common amongst human malignant tumors.The recent research indicate that the aberrant promoter methylation plays an important role in the progression of tumor.This review summarizes the role of three suppressor genes APC, RASSF1A and WIF-1 and methylation in the carcinogenesis of digestive system.
- digestive system neoplasms /
- genes /
- tumor suppressor /
- proto-oncogenes /
- DNA methylation /
- promoter regions (genetics) /
- genes

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参考文献(34)

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