Abstract: Objective Clinical analysis of 214 cases of early-mid stage chronic severe hepatitis B was performed to explore the effects of integrated treatment and the prognosis of related factors.Methods All the cases were treated with routine integrated traditional and western medicine, including hepatocytes protection, jaundice-relieving, antivirus, support and other symptomatic treatments.Results The total effective rate was 63.1% from 214 cases of chronic severe hepatitis B and ineffective rate was 36.9%.It shows that there are significant improvements in serum total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, prothrombin activity, total cholesterol, triglycerides, HBV DNA and other indicators between pretreatment and treatment outcome (P<0.05) .The significant prognostic factors involve the use of different anti-virus drug, electrolyte disturbances, hepatorenal syndrome and the chronic severe hepatitis B stage after treatment (P<0.05) .Among different groups of various antiviral drugs, entecavir group and lamivudine group appears to be more effective (P<0.05) .Conclusion Integrated traditional and western medicine treatment can achieve good therapeutic effects for early-mid stage chronic severe hepatitis B patients.The prognosis of patients with electrolyte disturbances or hepatorenal syndrome is worse.Better effects may be obtained by using antiviral drugs such as entecavir or lamivudine.