苦参碱联合干扰素α-2b治疗转氨酶轻度升高慢性乙型肝炎患者的疗效观察

王旭; 袁成民; 吴谙诏; 鹿勇; 赵玉娟

苦参碱联合干扰素α-2b治疗转氨酶轻度升高慢性乙型肝炎患者的疗效观察

1. 菏泽医学专科学校
2. 济南市传染病医院

基金项目:

山东省教育厅科技发展计划项目(J07YE13)；

详细信息

中图分类号: R512.62
计量
- 文章访问数: 4067
- HTML全文浏览量: 18
- PDF下载量: 750
- 被引次数: 0
出版历程
- 出版日期: 2011-05-20

The observation of anti-viral effect of matrine combined with interferon α-2b on the chronic hepatitis B patients with mild transaminase elevations

Research funding:

摘要

摘要: 目的观察注射用苦参碱联合重组人干扰素α-2b对转氨酶轻度升高慢性乙型肝炎（CHB）患者的抗病毒疗效,并从细胞免疫学角度探讨其作用机制。方法研究对象为随机选择CHB轻度患者60例,苦参碱联合重组人干扰素α-2b组及重组人干扰素α-2b组各30例,观察治疗1个月ALT、AST及治疗3个月HBeAg定量、HBV DNA载量变化;同时采用流式细胞技术检测外周血淋巴细胞各亚群数量。结果治疗3个月HBV DNA载量、HBeAg定量显著降低,CD3+T、CD4+T和CD8+T细胞计数均显著升高,两组比较差异有统计学意义（P<0.01）。结论苦参碱联合重组人干扰素α-2b对于CHB转氨酶轻度升高的患者有较好的抗病毒疗效和安全性。
- 肝炎,乙型,慢性 /
- 干扰素α-2b /
- 苦参碱
Abstract: Objective To observe anti-viral effect of matrine combined with interferon α-2b on the chronic hepatitis B patients with mild transaminase elevations and study the mechanism of cellular immunology.Methods 60 cases of mild chronic hepatitis B were randomly divided into two groups: the group of matrine combined with recombinant human interferon α-2b and the monotherapy group of recombinant human interferon α-2b.The change of ALT, AST after one month of treatment, and titers of HBeAg and the load of HBV DNA after three months of treatment were detected respectively.In addition, the quantity of subpopulation of peripheral blood lymphocyte were also detected by flow cytometry.Results After the treatment, the titers of HBeAg and the load of HBV DNA significantly decreased and CD3+T, CD4+ and CD8+T significantly increased.There is obvious difference between the two groups (P<0.01) .Conclusion Matrine combined with recombinant human interferon α-2b has better anti-viral effect and is more safer for chronic hepatitis B patients with mild transaminase elevations.
- hepatitis B /
- chronic /
- interferon alfa-2b

HTML全文

参考文献(8)

[1]刘蕊, 刘军.干扰素治疗成人慢性乙型肝炎的疗效分析[J].解放军药学学报, 2010, 26 (2) :180-181.

[2]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) :324-329.

[3]Rushbrook SM, Hoare M, Alexander GJ.T-regulatorylymphocytes and chronic viral hepatitis[J].Expert Opin Biol Ther, 2007, 7 (11) :1689-1703.

[4]田志刚, 陈永艳.NK细胞的发育、分化与识别机制[J].中国免疫学杂志, 2009, 25 (1) :31-34.

[5]刘爱平, 庞晓英, 顾艺难.苦参碱抗肝纤维化临床研究[J].中西医结合肝病杂志, 2001, 12 (2) :71.

[6]姚光弼.临床肝脏病学[M].上海:上海科学技术出版社, 2004:360, 897.

[7]蔡雄, 王国俊, 瞿瑶, 等.苦参素注射液对慢性乙型肝炎疗效观察[J].第二军医大学学报, 1997, 18 (1) :47.

[8]You J, Sriplung H, Geater A, et al.Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B[J].World J Gastroenterol, 2008, 14 (7) :1112-1119.

施引文献

资源附件(0)

访问统计